tumor necrosis factor- α (tnf-α) plays an important role in diverse cellular events such as septic shock, induction of other cytokines, cell proliferation and apoptosis. tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is currently attracting great interest as a potential anticancer drug. trail could selectively induce apoptosis in tumor cells in vitro and in vivo by a deat...

introduction: formocresol is widely used in primary teeth pulpotomies; however it is known to have several side effects. the purpose of this study was to assess pulpal changes of primary teeth pulps after pulpotomy with sodium hypochlorite and formocresol. materials and methods: in this randomized clinical trial, 22 teeth were selected. these teeth were randomly divided into 2 groups (formocres...

Spontaneous laceration of the ascending aorta may result in (1) through-and-through laceration causing hemopericardium, (2) limited intramural dissection of blood (incomplete dissecting aneurysm), or (3) classical dissecting aneurysm. The latter is the most common manifestation. Background conditions include either extensive cystic medial necrosis (as may be seen in Marfan's syndrome) or hypert...

Seven patients with cerebral necrosis after radiotherapy for carcinoma of the nasopharynx are presented. The clinical features included seizures and a varying degree of intellectual impairment. In spite of significant mass effect on CT scan, the patients remained alert, ambulatory and independent. We believe that some cases of cerebral necrosis following radiotherapy for extra-cranial neoplasms...

Purpose. The association between transarterial chemoembolization- (TACE-) induced HCC tumor necrosis measured by the modified Response Evaluation Criteria In Solid Tumors (mRECIST) and patient survival is poorly defined. We hypothesize that survival will be superior in HCC patients with increased TACE-induced tumor necrosis. Materials and Methods. TACE interventions were retrospectively reviewe...

BACKGROUND AND PURPOSE We earlier reported that risk factors for stroke prepare brain stem tissue for a modified Shwartzman reaction, including the development of ischemia and hemorrhage and the production of tumor necrosis factor-alpha, after a provocative dose of lipopolysaccharide. In the present study, we sought to determine whether blood and central nervous system cells of rats with the st...

a modified Shwartzman reaction, including the development of ischemia and hemorrhage and the production of tumor necrosis factor-a, after a provocative dose of lipopolysaccharide. In the present study, we sought to determine whether blood and central nervous system cells of rats with the stroke risk factor of advanced age produce more proinflammatory and prothrombotic mediators than do those of...

OBJECTIVE To determine whether saline-enhanced dual probe bipolar radiofrequency ablation (RFA) using perfused-cooled electrodes shows better in-vitro efficiency than monopolar or single probe bipolar RFA in creating larger coagulation necrosis. MATERIALS AND METHODS RF was applied to excised bovine livers in both bipolar and monopolar modes using a 200 W generator (CC-3; Radionics) and the p...

INTRODUCTION Cutaneous infection is an uncommon presentation of mucormycosis, usually seen after trauma, at the site of surgical drains or after occlusive dressings. The involved area is erythematous and painful, with varying degree of central necrosis. We report the case of chronic coetaneous infection of one year duration and without apparent necrosis in an immunocompetant patient. CASE PRE...