We have developed a rat model of ischemic bowel necrosis associated with shock by injection of platelet-activating factor (PAF) or a combination of PAF and endotoxin. Recent investigations have shown that tumor necrosis factor (TNF) also induces shock and necrosis of the gastrointestinal tract. The morphological changes of TNF-induced bowel lesions are indistinguishable from those caused by PAF...

background host genetic and environmental factors are involved in development of gastric cancer. tumor necrosis factor (tnf)-î±| has a key role in helicobacter pylori -induced gastritis. we analyzed the association between tnf-î± polymorphism and the risk of gastric cancer in an iranian population residing in northeastern iran. materials and methods in a case-control study, the genotyping was c...

introduction:artifical sourace of radiation have increased worldwide average annual exposure of mankind and could especially affect rapidly dividing cells in gonads. since, radiation sensitivities of different components of primordial follicles, and the time required for their deplation have not been morphologically eatablished we decided to estimate the time required for depletion of primordia...

background : the cause of death is difficult to interpret in a road-traffic accident (rta) victim, because multiple injuries make it difficult to decide on the most fatal lesion, particularly when death is delayed by prompt medical intervention; and secondary haemorrhage, renal failure, fat embolism, systemic infections, myocardial or cerebral infarction – all comes under the potential differen...

conclusions traf6 plays an important role in the onset of colon cancer; therefore, drugs targeting it may have great clinical significance in the treatment of this disease. results the positive expression rate of traf6 in tumor tissues was 66.7%, which was significantly higher than in normal paracancerous tissues (18.5%). the positive expression rate of traf6 was significantly correlated with d...

epidemiological data suggest that arsenic ultimately results in cancer in different parts of the body. several synthetic therapeutic agents manifest inadequate potency with severe side effects against arsenic toxicity. the flesh of b. bengalensis , has long been used as an ethno-medicine in case of arthritis, blood-impurities, impaired immune system, conjunctivitis and liver anomalies. this pot...

background: despite the outbreak in dental science, oral and dental complications in alzheimer are of the unsolved problems. it is assumed that tumor necrosis factor-α, which is a key factor in alzheimer, has a relation with periodontal complications in patients with alzheimer disease. the present study evaluated the effect of chronic periodontitis on serum levels of tumor necrosis factor-α in ...

Aim. To explore the potential of perfusion CT for predicting deep pancreatic necrosis and duct injury as well determining treatment strategy. Materials methods. The prospective study included 74 patients hospitalized within 1–2 days acute pancreatitis. They were exposed to examination their arterial blood flow velocity. In 37 observations, a standard was also performed on day 3–9 depth configur...

 Abstract Fat necrosis secondary to pancreatitis can be either mild and self limited or create severe organ damage, but may rarely lead to abdominal opancreatic pseudotumor. We report a case of fat necrosis secondary to pancreatitis which clinically simulates transverse colon cancer.

Abstract Although necrosis is common in brain metastasis (BM), its biological and clinical significances remain unknown. We evaluated extent differences by primary cancer subtype correlated BM to overall survival post craniotomy. analyzed 145 patients receiving Necrosis tumor ratio (NTR) was measured. Patients were divided into two groups NTR: BMs with sparse abundant necrosis. Clinical feature...