نتایج جستجو برای: neb
تعداد نتایج: 571 فیلتر نتایج به سال:
The Ca(2+)-sensing receptor (CaSR) is the master regulator of whole-body extracellular free ionized [Ca(2+)]o. In addition to sensing [Ca(2+)]o, CaSR integrates inputs from a variety of different physiological stimuli. The CaSR is also expressed in many regions outside the [Ca(2+)]o homeostatic system, including the fetal lung where it plays a crucial role in lung development. Here, we show tha...
Nemaline myopathy (NM) is a congenital myopathy that can result in lethal muscle dysfunction and is thought to be a disease of the sarcomere thin filament. Recently, several proteins of unknown function have been implicated in NM, but the mechanistic basis of their contribution to disease remains unresolved. Here, we demonstrated that loss of a muscle-specific protein, kelch-like family member ...
Gamma-aminobutyric acid (GABA) is an important signaling molecule, both inand outside of the central nervous system (CNS), and serves a multitude of known physiological functions. GABA is synthesized from glutamic acid by a decarboxylation reaction that is catalyzed by the enzyme glutamic acid decarboxylase (GAD). In mammals, two isoforms of GAD are expressed, GAD65 and GAD67, which are encoded...
Nuclear envelope breakdown (NEB) and entry into mitosis are though to be driven by the activation of the p34cdc2-cyclin B kinase complex or mitosis promoting factor (MPF). Checkpoint control mechanisms that monitor essential preparatory events for mitosis, such as DNA replication, are thought to prevent entry into mitosis by downregulating MPF activation until these events are completed. Thus, ...
Nemaline myopathy is a type of the heterogeneous group of congenital myopathies. Generalized hypotonia, weakness, and delayed motor development are the main clinical features of the typical congenital form. Histopathology shows characteristic nemaline rods in the muscle biopsy. Mutations in at least 7 genes, including nebulin gene (NEB), proved to be responsible for this muscle disease. We pres...
We present a modified version of the nudged elastic band (NEB) algorithm to find minimum energy paths connecting two known configurations. show that replacing harmonic band-energy term with discretized Onsager–Machlup action leads NEB adaptive spring lengths automatically increase resolution path around saddle point potential surface. The method has same computational cost per optimization step...
Due to the scarcity of studies linking variability rainfall and population growth in capital cities Northeastern Brazil (NEB), purpose this study is evaluate multiscale interaction (annual seasonal), addition, detect their trends impact urban growth. For this, monthly data between 1960 2020 were used. In detection on annual seasonal scales was performed using Mann–Kendall (MK) test compared wit...
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