ncls, which are some of the most common degenerative disorders, often also cause progressive blindness. the diagnosis is suggested by characteristic inclusions, visible by electron microscope, in a skin or conjunctival biopsy specimen. during the last several years, the biochemical and genetic basis of the ncls has been elucidated. the ncls are characterized by the accumulation of autofluoresce...

Epstein-Barr Virus (EBV) Nuclear Antigen 1 (EBNA1)-mediated origin of plasmid replication (oriP) DNA episome maintenance is essential for EBV-mediated tumorigenesis. We have now found that EBNA1 binds to Ribosome Protein L4 (RPL4). RPL4 shRNA knockdown decreased EBNA1 activation of an oriP luciferase reporter, EBNA1 DNA binding in lymphoblastoid cell lines, and EBV genome number per lymphoblast...

UNLABELLED The NEXUS Class Library (NCL) is a collection of C++ classes designed to simplify interpreting data files written in the NEXUS format used by many computer programs for phylogenetic analyses. The NEXUS format allows different programs to share the same data files, even though none of the programs can interpret all of the data stored therein. Because users are not required to reformat...

The neuronal ceroid-lipofuscinoses (NCL) is a group of neurodegenerative disorders characterized by epilepsy, visual failure, progressive mental and motor deterioration, myoclonus, dementia and reduced life expectancy. Classically, NCL-affected individuals have been classified into six categories, which have been mainly defined regarding the clinical onset of symptoms. However, some patients ca...

Retinoblastoma (RB) is an intraocular childhood tumor which, if left untreated, leads to blindness and mortality. Nucleolin (NCL) protein which is differentially expressed on the tumor cell surface, binds ligands and regulates carcinogenesis and angiogenesis. We found that NCL is over expressed in RB tumor tissues and cell lines compared to normal retina. We studied the effect of nucleolin-apta...

A number of nuclease-deficient mutants of Bacillus subtilis were isolated and found to be concurrently asporogenous. The nuclease-deficient phenotype appeared to be associated with the spoOH sporulation locus. Spontaneously occurring sporogenous revertants concomitantly recovered the ability to produce extracellular nuclease activity. The position of the ncl mutation was determined using transf...

Traditional electric springs can only stabilize the voltage of critical loads (CL), while sacrificing operational stability non-critical (NCL), status these two is obviously unequal, exposure to fluctuating voltages for extended periods time be hazardous NCL. To solve this problem, a control method based on spring (ES) with switchable smart load (SSL) that does not distinguish between CL and NC...

The oncogenic Epstein-Barr virus (EBV) evades the immune system but has an Achilles heel: its genome maintenance protein EBNA1, which is essential for viral genome maintenance but highly antigenic. EBV has seemingly evolved a system in which the mRNA sequence encoding the glycine-alanine repeats (GAr) of the EBNA1 protein limits its expression to the minimal level necessary for function while m...

NULL Convention Logic (NCL) is one of the mainstream asynchronous logic design paradigms. NCL circuits use threshold gates with hysteresis. In this chapter, the transistor-level CMOS design of NCL gates is investigated, and various gate styles are introduced and compared to each other. In addition, a novel approach to design static NCL gates is introduced. The new approach is based on integrati...

Neuronal ceroid lipofuscinoses (NCL) are a group of genetically inherited encephalopathies, characterized by accumulation of autofluorescent lipopigment in neurons and several other cell types. These diseases are metabolic lysosomal storage disorders affecting mainly children, although some rare adult forms have also been discovered. They are clinically identified by mental and motor deteriorat...