Engineered antibody fragments offer faster delivery with retained tumor specificity and rapid clearance from nontumor tissues. Here, we demonstrate that positron emission tomography (PET) based detection of prostate specific membrane antigen (PSMA) in prostatic tumor models using engineered bivalent antibodies built on single chain fragments (scFv) derived from the intact antibody, huJ591, offe...

The year 2016 was a wonderful and important one for Zoological Research (ZR). In recognition of its impressive progress and great potential to develop into a leading journal in the field, ZR is now supported by the “Project for Enhancing International Impact of China STM Journals” (PIIJ) (Class B) (2016–2018). Having wide coverage, PIIJ is the most influential project in China for supporting an...

OBJECTIVE This study assessed how changing the Zirconia (Zr) substructure affected the color samples after they have been overlaid by the same shade of veneering ceramic. MATERIALS AND METHODS Three commercial Zr materials were tested in this study: Prettau(®) Zirconia (ZirKonZahn, Italy), Cercon (Dentsply, Germany) and InCoris ZI (Sirona, Germany). For each system, 15 disk-shaped specimens (...

UNLABELLED Transforming growth factor-β (TGF-β) promotes cancer invasion and metastasis and is therefore a potential drug target for cancer treatment. Fresolimumab, which neutralizes all mammalian active isoforms of TGF-β, was radiolabeled with (89)Zr for PET to analyze TGF-β expression, antibody tumor uptake, and organ distribution. METHODS (89)Zr was conjugated to fresolimumab using the che...

Zirconium (Zr) is an important alloying element to Mg-Zn-based alloy system. In this paper, we report the formation of the β-type precipitates on the nanoscale Zr-rich particles in a Mg-6Zn-0.5Cu-0.6Zr alloy during ageing at 180°C. Scanning transmission electron microscopy examinations revealed that the nanoscale Zr-rich [0001]α rods/laths are dominant in the Zr-rich core regions of the as-quen...

The 3D morphological evolution of titanium foams as they undergo a two-step fabrication process is quantitatively characterized through x-ray microand nano-tomography. In the first process step, a Cu–Ti–Cr–Zr prealloy is immersed in liquid Mg, where Cu is alloyed with Mg while a skeleton of crystalline Ti–Cr–Zr is created. In the second step, the Mg–Cu phase is etched in acid, leaving a Ti–Cr–Z...

The monomeric title zirconium(IV) compound, [Zr(C(12)H(21)N(2)Si)(2)Cl(2)], was prepared by the metathetical reaction of [LiN(SiMe(2)NMe(2))(2,6-Me(2)C(6)H(3))](2) with zirconium tetra-chloride. The Zr(IV) atom is N,N'-chelated by the N-silylated anilido ligand. Along with two Cl atoms, the six-coordinated Zr(IV) atom demonstrates a highly distorted octa-hedral geometry. The two ligands around ...

EXAFS spectra for all K absorption edges and X-ray scattering data have been obtained on an amorphous Fe-Zr sample prepared by mechanical alloying and a rapidly quenched Co-Zr one. Partial pair distribution fnnctions have been determined as a solution of an inverse ill-posed problem for the system of integral equations describing combined experimental data. For Fe-Zr and Ca-Zr amorphous alloys ...

Very recently the atomic masses of neutron-rich Zr isotopes, from Zr to Zr, have been measured with high precision. Using a schematic Interacting Boson Model (IBM) Hamiltonian, the evolution from spherical to deformed shapes along the chain of Zr isotopes, describing at the same time the excitation energies as well as the two-neutron separation energies, can be rather well reproduced. The inter...