In individuals with cerebral palsy (CP), smaller muscle and atrophy are present at young age. Many people with CP also experience a decline in gross motor function as they age, which might be explained by the loss of muscle mass. The clinical observation of muscle wasting has prompted a comparison with sarcopenia in older adults, and the term accelerated musculoskeletal ageing is often used to ...

The effects of copper on the ageing precipitation behavior of as-quenched and pre-aged AA6016 aluminum alloy were studied by differential scanning calorimetry (DSC), Vickers hardness measurement and transmission electronic microscopy (TEM). The results indicate that the addition of copper facilitates the growth of clusters (GP I) to the critical size during pre-ageing. Therefore, the addition o...

There is clear heritability of human longevity. However, the genetics of ageing is likely to be complex. Evolution theory tells us not to expect genes that have been selected to promote ageing. Ageing is not programmed but results from accumulation of somatic damage, owing to limited investments in maintenance and repair. Genes controlling the levels of activities, such as DNA repair and antiox...

Immunosurveillance requires the migration of lymphocytes and their activation to induce proliferation and effector function. Effective immunity requires an optimal supply of nutrients to lymphocytes. Cells contain nutrient sensing apparatus such as adenosine 5'-monophosphate-activated protein kinase (AMPK) that surveys intracellular ATP levels. Immunity declines during ageing and one possibilit...

When does (sexual) ageing begin? Ageing is the natural progression of changes in structure and function that occurs with the passage of time in the absence of known disease [1] Women experience reproductive aging (hypothalamicpituitary-ovarian axis) superimposed on chronological aging. Reproductive aging begins at birth, with the progressive destruction of the oocyte’s reserve, and proceeds as ...

Atom Probe Tomography (APT) analysis and hardness measurements were used to characterize the early stages of precipitation in an Al-0.51 at%Mg-0.94 at%Si alloy as reported in the accompanying Acta Materialia paper [1]. The changes in microstructure were investigated after single-stage or multi-stage heat treatments including natural ageing at 298 K (NA), pre-ageing at 353 K (PA), and automotive...

Molecular chaperones dampen the effect of damaging mutations that would otherwise be removed from the population by natural selection. Here, I propose that the development of modern medical practice depressed this process, leading to a rise of phenotypically silent mutations in the genome. The background of misfolded proteins increases during ageing and, by competition, prevents the chaperone-m...

“To be forever young doesn’t mean to be 20. It means to be optimist, to feel good, to have an ideal to fight for and to achieve it” said Prof. Ana Aslan. Human ageing and longevity are complex and multi-factorial traits that result from a combination of environmental, genetic, epigenetic and stochastic factors. Ageing refers to the time sequential deterioration including weaness, susceptibility...