نتایج جستجو برای: nanomicelles

تعداد نتایج: 226  

Objective: In the current investigation, we aimed to study the combined cytotoxicity of curcumin, as a nanomicellar formulation, and galbanic acid (Gal), dissolved in DMSO against the murine C26 and human Caco-2 colon carcinoma cells. Further, curcumin potential for cisplatin and doxorubicin (Dox) co-therapy was studied. <span styl...

Journal: :research in pharmaceutical sciences 0
farshid hassanzadeh 1department of medicinal chemistry and isfahan pharmaceutical sciences research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i.r. iran. maryam farzan 2department of medicinal chemistry, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i.r. iran. jaleh varshosaz 3department of pharmaceutics, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i.r. iran. ghadam ali khodarahmi 2department of medicinal chemistry, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i.r. iran. sahar maaleki 2department of medicinal chemistry, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i.r. iran. mahboubeh rostami 1department of medicinal chemistry and isfahan pharmaceutical sciences research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i.r. iran.

in this study, poly(ethylene-co-vinyl alcohol) (evoh) as a novel biocompatible polymeric scaffold was surface modified by succinylation to get evohs and further pegylated to improve structural properties using methoxypolyethylene glycol (5000 da) succinate (pegs) along with targeting with retinoic acid (ra) to get final modified active and passive targeted conjugate (pegs-evohs-ra) to evaluate ...

2014
Xiaolan Zhang Ke Liu Yixian Huang Jieni Xu Jiang Li Xiaochao Ma Song Li

We have developed a dual-functional nanocarrier composed of a hydrophilic polyethylene glycol (PEG) and a hydrophobic farnesylthiosalicylate (FTS, a nontoxic Ras antagonist), which is effective in delivery of hydrophobic anticancer drug, paclitaxel (PTX). To facilitate the retention of the therapeutic activity of the carrier, FTS was coupled to PEG via a reduction-sensitive disulfide linkage (P...

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