Abstract Background Photodynamic therapy (PDT) is a clinically implemented modality to combat malignant tumor, while its efficacy largely limited by several resistance factors from tumor microenvironment (TME), such as hypoxia, anti-oxidant systems, and ATP-dependent adaptive resistances. The aim of this work construct multifunctional nanoplatform remodel multiple resistant TME for enhanced PDT...

Solute/impurity segregation and precipitation at grain boundaries (GBs) in a nuclear reactor pressure vessel (RPV) steel were investigated using laser-assisted atom probe tomography (APT): RPV surveillance test specimens irradiated in a commercial nuclear reactor to neutron doses of 0.83 © 1019 n·cm12 (low-dose) and 5.1 © 1019 n·cm12 (high-dose), corresponding to in-service exposure of 35 and 3...

Protein phosphorylation is an important post-translational modification involved in the regulation of many cellular processes. Mass spectrometry has been successfully used to identify protein phosphorylation in specific pathways and for global phosphoproteomic analysis. However, phosphoproteomics approaches do not evaluate the subcellular localization of the phosphorylated forms of proteins, wh...

The properties of nanoparticles and the performance of products made with nano-sized precursors significantly depend on the shape of the particle size distribution (PSD) or more precisely the broadness of the PSD, the modality and of course the specific particle sizes covered by the PSD. Especially the controlled adjustment of particle size is of interest due to the size-dependent physical and ...

General considerations. All manipulations of air-sensitive compounds were performed using standard Schlenk techniques under argon atmosphere. NMR spectra were recorded with either a Bruker ARX 300, Bruker Avance DRX 600 or Varian INOVA-400 spectrometer. H and C NMR chemical shifts were referenced to H and C NMR signals of the deuterated solvents, respectively. High temperature NMR measurements ...

Over the last years a new type of tubular plug flow reactor, the segmented flow tubular reactor (SFTR), has proven its versatility and robustness through the water-based synthesis of precipitates as varied as CaCO3, BaTiO3, Mn(1-x)NixC2O4·2H2O, YBa oxalates, copper oxalate, ZnS, ZnO, iron oxides, and TiO2 produced with a high powder quality (phase composition, particle size, and shape) and high...

During the past decades, large-scale national neutron sources were developed in Asia, Europe, and North America. Complementing such efforts, compact hadron beam complexes and neutron sources intended to serve primarily universities and industrial institutes were proposed and some have recently been established. Responding to the demand in China for multidisciplinary fundamental and applied rese...