To overcome the problems associated with conventional liposomes in transdermal drug delivery like limited penetration ability and poor stability, in this article we report a new generation of cell penetrating peptide polyarginine containing nano-liposomes conjugated with carbon dots. The newly synthesized, cost-effective liposomic precursors were used for the fabrication of liposomes. The resul...

The successful application of various nanoplatforms in medicine under in vitro conditions has generated some interest in medicine-nanotechnology. The spinel-type MnZn ferrite nano powders were synthesized by Solution Combustion Synthesis (SCS) method. The important classes of soft magnetic materials Mn-Zn ferrites have high magnetic permeability and low power losses.Mn-Zn-Fe2O4 have a spinal st...

In the recent decades, polymers are widely used as biomaterials due to their favorable properties such as good biocompatibility, easy design and preparation, a variety of structures and interesting bio-mimetic character. Especially in the field of smart drug delivery, polymer played a significant role because it can deliver therapeutic agents directly into the intended site of action, with supe...

A drug-delivery microdevice integrating pH-responsive nano-hydrogel particles functioning as intelligent nano valves is described. The polymeric microdevices are monolithic without requiring peripheral control hardware or additional components for controlling drug-release rates. pH-responsive nanoparticles were synthesized and embedded into a composite membrane. The resulting pH-responsive comp...

Microfluidic technology is a valuable tool for realizing more in vitro models capturing cellular and organ level responses rapid animal-free risk assessment of new chemicals drugs. cell-based devices allow high-throughput screening flexible automation while lowering costs reagent consumption due to their miniaturization. There growing need faster approaches drug development safety (Registration...

The development of small molecules is essential to modulate the cellular functions of biological targets in living system. Target Guided Synthesis (TGS) approaches have been used for the identification of potent small molecules for biological targets. We herein demonstrate an innovative example of TGS using DNA nano-templates that promote Huisgen cycloaddition from an array of azide and alkyne ...

Ultrasound is an innovative technology that is used successfully for sonochemical synthesis, deagglomeration, dispersion, emulsifying, functionalization and activation of particles. Particularly in nanotechnology, the ultrasonication is an essential technique for the synthesis and processing purposes of nano-size materials. Since nanotechnology has gained this outstanding scientific interest, n...

To date there has not been any report on catan-ionic hybrid lipidic nano-carriers, let alone a report on applying them to deliver insoluble anti-tumor drugs. Catan-ionic hybrid lipidic nano-carriers containing curcumin (CUR-C-HLN) inherit the merits of catan-ionic systems, hybrid lipidic systems and nano-structured carriers (the second-generation substitute of solid lipidic nano-systems). Catan...

Drug-loaded mono- and multilayer composite membranes were prepared. The composites, based on nano-fibrillated bacterial cellulose, nano-powdered polyvinyl alcohol, all biocompatible biodegradable, characterized in terms of basic factors related to drug diffusivity mass transfer: swelling ability, water solubility, vapor permeability. Tetracycline hydrochloride was used this case as model. Drug ...

Herbal medicines have been widely used all over the world since ancient times and have been recognized by physicians and patients for their better therapeutic value as they have fewer adverse effects as compared with modern medicines. Herbal therapeutics can be achieved by Drug Delivery systems. This herbal treatment helps to increase the therapeutic value by reduce the toxicity and side effect...