نتایج جستجو برای: nano carriers
تعداد نتایج: 95136 فیلتر نتایج به سال:
Synthesis and functionalization of PLGA nanoparticles for cancer therapeutic applications.
Honey is an excellent source of polyphenolic compounds that are effective in attenuating quorum sensing (QS), a chemical process of cell-to-cell communication system used by the opportunistic pathogen Pseudomonas aeruginosa to regulate virulence and biofilm formation. However, lower water solubility and inadequate bioavailability remains major concerns of these therapeutic polyphenols. Its ther...
The effect HBOC-201 and sodium nitrite resuscitation after uncontrolled haemorrhagic shock in swine.
BACKGROUND Development of Haemoglobin-based oxygen carriers (HBOCs) as blood substitutes has reached an impasse due to clinically adverse outcomes attributed to vasoconstriction secondary to nitric oxide (NO) scavenging. Studies suggest haemoglobin exhibits nitrite reductase activity that generates NO and N(2)O(3); harnessing this property may offset NO scavenging. Therefore, the effects of con...
Statement of Purpose: Various nanoparticle systems with a long blood circulation time and a high tumor accumulation have been reported for cancer diagnosis and treatment based on their EPR (enhanced permeability and retention) effect [1,2]. Here, we prepared several Pluronic-based nano-carriers attached with an NIR dye, and characterized their cellular uptake and in-vivo tumor targeting efficie...
Amphiphilic calix[4]arenes were designed as phospholipid mimics by incorporating PO3H2 or NMe3(+) head groups. Using PC12 cells and three stressors (H2O2, menadione and glutamate), we established safe calix[4]arene levels that are able not only to deliver antioxidant payloads of curcumin, but intriguingly also have inherent antioxidant properties. The calix[4]arenes appear to be potent syntheti...
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