Objective(s):Some pathologic situations such as diabetes and metabolic syndrome are associated with alternation in nitric oxide level. Incidence of these condition increases with aging. On the other hand, insulin secretion is modulated by nitric oxide, and nitric oxide synthase (NOS) activity is also altered in diabetes. In this study, modification in the enzyme activity associated with aging a...

objective(s) high blood glucose induces molecular, cellular, morphological and behavioral changes in the brain. metabolic disturbances, contribute to the hippocampus injury and development of partial focal seizures. the aim of this study was to investigate the effects of infantile repeated hyperglycemia on neuronal density of hippocampal ca3region in newborn wistar male rats and its effect on c...

background and objectives rheumatoid arthritis (ra) is a chronic inflammatory disease which is characterized by joint swelling, and synovial inflammation. c reactive protein (crp) and ceruloplasmin (cp) are identified as important biomarkers of ra and various inflammatory diseases. curcumin, a widely used yellow color spice is the most active component of curcuma longa l (turmeric). curcumin co...

Background. Omentin-1, a novel adipokine expressed in visceral adipose tissue, is negatively correlated with insulin-resistance and obesity. Objective(s). The aim of this study was to investigate the effect of eight weeks of high-intensity interval training on omentin-1 gene expression in visceral adipose tissue and insulin-resistance in male wistar rats. Methods. A total of 26 male Wis...

One of the characteristics metabolic syndrome (MetS) is low high-density lipoprotein (HDL) levels. Jamblang leaves (Syzygium cumini L.) contain various phytochemicals, which have antihyperglycemic, antihyperlipidemic, and antioxidant properties. This study aims to demonstrate effectiveness ethanol extract jamblang in increasing HDL levels Wistar rats model MetS. A pretest-posttest with a contro...

The aim of this study to establish the effect systemic N-acetylcysteine (NAC) administration on oxidative–antioxidative balance, inflammatory markers, and collagen production during wound healing in diabetes. A total 24 male Wistar albino rats were randomly divided into 4 groups: control, streptozotocin-induced diabetic model, NAC treatment group, model with treatment. dorsal circular was creat...

Background: Antioxidants such as α-tocopherol (vitamin E) and β-carotene (vitamin A) play an important role in protective effect of repeated brief periods of ischemia, namely ischemic preconditioning (IPC). Values of these antioxidants were investigated and compared after induction of ischemia reperfusion (IR) and kidney IPC in both male and female rats. Methods: Forty eight Wistar rats were di...

aflatoxins (afs) are natural contaminants of feed and feedstuffs, thus the study of the noxious effects ofthese agents on the male reproductive system is of outstanding importance. our aim for this study is theevaluation of the effects of oral administration of aflatoxin b1 on the reproductive hormonal changes in adult male rat. twenty eight wistar strain male rats were selected for this study....

Background: Liver fibrogenesis will produce α-smooth muscle actin (α-SMA) expression and a continuous inflammatory process, seen through the neutrophil lymphocyte ratio (NLR). The combination of mesenchymal stem cells bovine colostrum is novel strategy for repairing hepatic fibrosis tissue. To assess to reduce α-SMA NLR levels in Wistar rats after 50% fibrotic liver resection.
 Methods: Th...