The naked mole-rat (Heterocephalus glaber) is a long-lived, cancer resistant rodent and there is a great interest in identifying the adaptations responsible for these and other of its unique traits. We employed RNA sequencing to compare liver gene expression profiles between naked mole-rats and wild-derived mice. Our results indicate that genes associated with oxidoreduction and mitochondria we...

The gravitational collapse of a thick cylindrical shell of dust matter is investigated. It is found that a spacetime singularity forms on the symmetry axis and that it is necessarily naked, i.e., observable in principle. We propose a physically reasonable boundary condition at this naked singularity to construct the solution including its causal future. This boundary condition enables us to con...

For life to survive outside the biosphere, it must be protected from UV light and other radiation by exterior shielding or through sufficient inherent resistance to survive without protection. We tested the plausibility of inherent resistance in plant seeds, reporting in a previous paper that Arabidopsis thaliana and tobacco (Nicotiana tabacum) seeds exposed for 558 days outside the Internation...

The gravitational collapse of a cylindrical thick shell of dust matter is investigated. A spacetime singularity forms at the symmetry axis and it is necessarily naked, i.e., observable in principle. We propose a physically reasonable boundary condition at the naked singularity to construct the solution including its causal future. This boundary condition enables us to construct the unique conti...

The naked mole-rat (Heterocephalus glaber) is one of the most promising models used to study genome maintenance systems, including the effective repair of damage to DNA. The naked mole-rat is the longest lived rodent species, which is extraordinarily resistant to cancer and has a number of other unique phenotypic traits. For at least 80% of its lifespan, this animal shows no signs of aging or a...

Small interfering RNAs (siRNAs) therapy has opened exceptional advantageous opportunity for the treatment of diseases. Usually naked siRNA are subjected to internal harsh environment and rapidly degraded by RNases after administration. To overcome this issue various nanodelivery platforms have been developed and utilized in drug delivery due to narrowed size distribution, improved bioavailabili...

An outstanding problem in gravitation theory and relativistic astrophysics today is to understand the final outcome of an endless gravitational collapse. Such a continual collapse would take place when stars more massive than few times the mass of the sun collapse under their own gravity on exhausting their nuclear fuel. According to the general theory of relativity, this results either in a bl...

Recently Hertog, Horowitz, and Maeda have argued that cosmic censorship can be generically violated in string theory in anti-de Sitter spacetime by considering a collapsing bubble of a scalar field whose mass saturates the Breitenlohner-Freedman bound. We study this system numerically, and find that black holes form rather than naked singularities, implying that cosmic censorship is upheld.

We show the existence of timelike naked singularities which are not hidden by a horizon and which are associated to spherically symmetric (noncompact) matter sources extending from r = 0 to r = ∞. Our asymptotically flat solutions do represent observable timelike naked singularities where the scalar curvature R and volume mass density ρ(r) are both singular at r = 0. To finalize we explain the ...

The gravitational collapse of spherical, barotropic perfect fluids is analyzed here. For the first time, the final state of these systems is studied without resorting to simplifying assumptions such as self-similarity using a new approach based on non-linear o.d.e. techniques, and formation of naked singularities is shown to occur for solutions such that the mass function is analytic in a neigh...