Aims/Objectives/Background Paracetamol overdose is the most common drug in UK. The standard treatment of toxicity intravenous N-acetylcysteine (NAC) which usually given as a 21-hour infusion UK hospitals. A 12-hour known ‘SNAP’ regimen has been implemented some centres and appears on TOXBASE. SNAP associated with fewer anaphylactoid reactions than treatment. was initiated two District General H...

Background We decided to conduct this study with the aim of investigating effects N-Acetylcysteine (NAC) on obesity complications and senescence visceral adipose tissue in obese adults. Methods analysis The present was conducted as a randomized clinical trial (RCT) (Clinical registry number: IRCT20220727055563N1) 40 adults candidates for bariatric surgery, who were randomly assigned receive 600...

Rifampin, an antibiotic widely used for the treatment of mycobacterial infections, produceshepatic, renal and bone marrow toxicity in human and animals. In this study, the protectiveeffects of vitamin C and n-acetylcysteine (NAC) on the toxicity of rifampin on HepG2 cellswere investigated.Human hepatoma cells (HepG2) were cultured in 96-well M of rifampin in the presence ofmicroplate and expose...

Rifampin, an antibiotic widely used for the treatment of mycobacterial infections, produceshepatic, renal and bone marrow toxicity in human and animals. In this study, the protectiveeffects of vitamin C and n-acetylcysteine (NAC) on the toxicity of rifampin on HepG2 cellswere investigated.Human hepatoma cells (HepG2) were cultured in 96-well M of rifampin in the presence ofmicroplate and expose...

Oxidative stress and especially its connection with many diseases has been discussed much recently. Among markers of oxidative stress there appear new and quite specific ones called advanced oxidation protein products (AOPPs). We tried to influence the level of AOPPs by an antioxidant therapy with N-acetylcysteine. Fourteen individuals with many cardiovascular risk factors were examined. All th...

J Nutr. 2008 Oct;138(10):1872-9. N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis. Baumgardner JN, Shankar K, Hennings L, Albano E, Badger TM, Ronis MJ. Departments of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. BACKGROUN D: A "2-hit" model for nonalcoholic steatohepatitis (NASH) h...

The anthropogenic release of Hg is associated with an increased human exposure risk. Since Hg2+ and MeHg+ have a high affinity for thiols, their interaction L-glutathione (GSH) within mammalian cells fundamentally involved in toxicological chemistry excretion. To gain insight into the these mercurials multiple small molecular weight we investigated competitive interactions GSH N-acetylcysteine ...

This study investigated the effect of cigarette smoke exposure and the potential protection N-acetylcysteine (NAC) in rat lungs. Forty-eight rats were exposed to cigarette smoke (CS) for 10 weeks, without (CS group) or with (CS+NAC group) oral intake of NAC 200 mg x rat(-1) x day(-1), or to fresh air (Control). All rat lungs were assessed in terms of lung function, ventilation distribution (nit...