Abstract Background Azathioprine is commonly used in the treatment of inflammatory bowel disease (IBD) either as monotherapy or combination with anti-TNF agents. has numerous side-effects (SA) including leukopenia, pancreatitis and drug-induced liver injury (DILI). At our centre, dedicated IBD nurses play a central role educating patients regarding potential SA importance blood test monitoring....

International evidence indicates that higher terms of trade levels and lower terms of trade volatility contribute to enhanced growth outcomes, especially for commodity-export and developing countries. New Zealand’s terms of trade have been high and remarkably stable since the early 1990s compared with past experience. We analyse the proximate reasons behind these high, stable terms of trade and...

Can part of Africa’s current underdevelopment be explained by its slave trades? To explore this question empirically, I combined data from ship records with data from various historical documents reporting slave ethnicities, and construct estimates of the number of slaves exported from each country during Africa’s slave trades between 1400 and 1900. I find a strong robust negative correlation b...

The Rho family of GTPases control diverse biological processes, including cell morphology and mitogenesis. We have identified WASP, the protein that is defective in Wiskott-Aldrich syndrome (WAS), as a novel effector for CDC42Hs, but not for the other Rho family members, Rac and Rho. This interaction is dependent on the presence of the G protein-binding domain. Cellular expression of epitope-ta...

Solvent fractionation of high oleic-high stearic (HOHS) sunflower oil was studied to determine the best solvent to use (hexane or acetone) in terms of the operational parameters and properties of the final stearins. Acetone fractionation on two types of HOHS sunflower oils (N17 and N20) was carried out at temperatures from 5 to 10 °C using micelles with different oil/solvent ratios. Acetone was...

Many neurodegenerative diseases are linked to amyloid aggregation. In Huntington's disease (HD), neurotoxicity correlates with an increased aggregation propensity of a polyglutamine (polyQ) expansion in exon 1 of mutant huntingtin protein (mHtt). Here we establish how the domains flanking the polyQ tract shape the mHtt conformational landscape in vitro and in neurons. In vitro, the flanking dom...

Wounding of tissue induces cellular responses that ultimately result in wound repair. Studies in tissue culture model systems indicate that these responses include induction of AP-1 regulated genes, cell migration and mitogenesis which are also characteristic of cellular responses to growth factors. Investigations have identified cellular ras proteins as critical components of growth factor-sti...

In this study, we show that historic events have a long term incidence on institutional development. Within the framework of the paper, we attempt to provide insights into a historical dimension that has not received the scholarly attention it deserves in empirical literature, notably: African resistance in the face of colonization. The main finding suggests that contemporary institutions in Af...