The spermine analogue N1,N11-diethylnorspermine (DENSPM) has been shown to induce the polyamine-acetylating enzyme spermidine/spermine N1-acetyltransferase, disrupt polyamine pool homeostasis, and inhibit tumor growth. DENSPM is currently being developed as an anti-neoplastic agent and is about to enter Phase II clinical trials. In this report, the antitumor efficacy of DENSPM was evaluated aga...

Given a complex m n matrix A; we index its singular values as 1 (A) 2 (A) ::: and call the value E (A) = 1 (A)+ 2 (A)+ ::: the energy of A; thereby extending the concept of graph energy, introduced by Gutman. Koolen and Moulton proved that E (G) (n=2) (1 + p n) for any graph G of order n and exhibited an in…nite family of graphs with E (G) = (v (G) =2) 1 + p v (G) . We prove that for all su¢ ci...

PURPOSE Evoked potentials were recorded in patients with DCD to evaluate the integrity the afferent pathways and to rule out the presence of any neurological lesions. MATERIAL AND METHODS Two boys: 5 and 16 years old with recognized DCD were examined. Battery of tests: short-latency somatosensory evoked potentials (SEP), pattern-reversal visual evoked potentials (VEP), cognitive event-related...

The polyamine analogue, N1-ethyl-N11-[(cycloheptyl)methyl]-4,8-diazaundecane (CHENSpm)-induced programmed cell death in NCI H157 cells is accompanied by cytochrome c release, the loss of mitochondrial membrane potential, activation of caspase-3, caspase-mediated poly(ADP-ribose) polymerase cleavage, G2-M arrest, and DNA and nuclear fragmentation. Overexpression of Bcl-2 completely inhibits CHEN...

We examine the question of whether transactable forms of privately issued, demandable debt are better used as “banknotes” or “checks.” The distinction between the two is that a check must be redeemed by the issuing bank with each use, whereas a banknote can circulate. We find that the answer to the question depends critically on the cost of early redemption. If this cost is small, banknotes wil...

We have analyzed the Percus-Yevick ~PY! and the mean spherical model ~MSM! equation for an N-component system of sticky hard spheres. The PY approximation leads to a set of N(N11)/2 coupled quadratic equations for the unknown coefficients. While for this closure, the pair distribution functions have to be calculated numerically, we can proceed in the MSM one step further if we assume a Lorentz-...

Streptomyces sp. N11-50 was isolated from deep-sea water and found to produce diketopiperazine (DKP) compounds such as albonoursin cyclo(Phe-Leu). This study aimed reveal the potential synthesize diverse nonribosomal peptide polyketide other secondary metabolites different DKP after clarifying taxonomic position. Strain identified albus, it showed 100% 16S rRNA gene sequence similarities 95.5% ...

Glioblastoma multiforme (GBM) is one of the most therapeutically refractory human cancers. Elevated cellular polyamine levels are a common feature of cancer cells, including GBM cells, and the polyamine pathway has been explored as a potential therapeutic target to inhibit polyamine biosynthesis or activate polyamine catabolism. In this study, we investigated the effect of N1,N11-diethyl-norspe...