BACKGROUND Dietary n-3 polyunsaturated fatty acids (PUFAs) derived from fish may reduce the incidence of sudden cardiac death (SCD). In addition, wine drinking is suggested to have a protective effect against cardiovascular death. METHODS AND RESULTS We included 291 patients referred for coronary angiography in whom ischemic heart disease was suspected and all of whom completed a food questio...

Commentary Ramsden and colleagues provide an updated meta-analysis of the effects of dietary LA for secondary prevention of CHD and death, adding data from the SDHS, which was conducted from 1966 to 1973. A central question focuses on the CV effects of replacing saturated fat in the diet with n-6 (“omega-6”) PUFAs, primarily in the form of LA, compared with replacing saturated fat with a combin...

the objective of the present study was to determine chemical composition and fatty acid profile of common kilka ,clupeonella cultriventris caspia, in the caspian sea. the chemical analysis revealed that the protein and lipid content of common kilka were 15.05 and 6.5% of the fresh weight, and total mufa, pufa and sfa were found to be 37.00, 32.89 and 29.03% respectively. palmitic acid (16:0) am...

Free fatty acids and the risk of sudden death • Elevated circulating free fatty acids have been reported to be a risk factor for sudden death. In the Paris Prospective Study reported by Jouven et al. [ 3 ], 5250 men were observed over a mean follow-up period of 22 years. The concept that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) may have potential health benefits has been supported by e...

With the unsatisfaction of monoamine-based pharmacotherapy and the high comorbidity of other medical illness in depression, the serotonin hypothesis seems to fail in approaching the aetiology of depression. Based upon the evidence from epidemiological data, case-control studies of phospholipid polyunsaturated fatty acids (PUFAs) levels in human tissues, and antidepressant effect in clinical tri...

N-3 polyunsaturated fatty acids (PUFAs) improve endothelial function. The arachidonic acid-derived metabolites (epoxyeicosatrienoic acids (EETs)) are part of the endothelial hyperpolarization factor and are vasodilators independent of nitric oxide. However, little is known regarding the regulation of EET concentration by docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) in blood vessel...

Stroke is the third commonest cause of death following cardiovascular diseases and cancer. In particular, in recent years, the morbidity and mortality of stroke keep remarkable growing. However, stroke still captures people attention far less than cardiovascular diseases and cancer. Past studies have shown that oxidative stress and inflammation play crucial roles in the progress of cerebral inj...

We have recently identified a neuroprotective role for omega-3 polyunsaturated fatty acids (n-3 PUFAs) in a toxin-induced mouse model of Parkinson's disease (PD). Combined with epidemiological data, these observations suggest that low n-3 PUFA intake is a modifiable environmental risk factor for PD. In order to strengthen these preclinical findings as prerequisite to clinical trials, we further...

Dietary n-3 polyunsaturated fatty acids (PUFAs), as compared with n-6 PUFAs, suppress cellular production of prostaglandins and tumor cell growth both in vitro and in vivo. However, the mechanism by which n-3 PUFAs suppress tumor growth is not understood. We investigated whether the suppression of tumor cell growth by dietary n-3 PUFAs is mediated through inhibition of cyclooxygenase (COX). A c...

Long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) have blood pressure lowering and antithrombotic effects, which may benefit hypertensive patients. Increased plasma concentration of von Willebrand factor (vWF), a procoagulant glycoprotein, has been identified in patients with severe hypertension, with some, but not all studies showing an increase with mild hypertension. In this stud...