A route to cationic tungsten alkylidyne N-heterocyclic carbene (NHC) complexes of the general formula [W(CR)X2(NHC)(tBuCN)y+B(ArF)4–] (R = tBu, C6H4-4-OMe; X Br, Cl, OTf; NHC 1,3-dimesityl-1,3-dihydro-2H-imidazol-2-ylidene, IMes; 1,3-bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene, IDipp; 1,3-dimesityl-4,5-dichloro-1,3-dihydro-2H-imidazol-2-ylidene, IMesCl2; y 1, 2; ArF 3,5-bis(tri...

Methods for the construction of thiazolo-, thiazino-, and thiazepino-2H-indazoles from o-nitrobenzaldehydes or o-nitrobenzyl bromides and S-trityl-protected 1°-aminothioalkanes are reported. The process consists of formation of the requisite N-(2-nitrobenzyl)(tritylthio)alkylamine, subsequent deprotection of the trityl moiety with TFA, and immediate treatment with aq. KOH in methanol under Davi...

Stereoselective Cycloaddition of 1-glucosyl-1,3butadienes with tert-Butyl-2H-azirine-3carboxylate, Glyoxylates and Imines M. José Alves*, I.G. Almeida, A. Gil Fortes*, A.P. Freitas Departamento de Química, Universidade do Minho, Campus de Gualtar, 4710-057, Braga, Portugal. Universidade Fernando Pessoa, R. Carlos da Maia, 298, 4200-150 Porto, Portugal. Glucose diene derivatives have been reacte...

The early adoption of digital health solutions in the treatment growth disorders has enabled collection and analysis more than 10 years real-world data using easypod™ connect platform. Using this rich dataset, we were able to study impact engagement on three key treatment-related outcomes: adherence, persistence use, growth. In total, for 17,906 patients available. features, regularity injectio...

An oxidative reaction for the synthesis of 4-alkyl-substituted dihydroisoquinolin-1(2H)-ones with N-allylbenzamide derivatives as starting materials has been developed. The radical alkylarylation reaction proceeds through a sequence of alkylation and intramolecular cyclization. The substituent on the C-C double bond was found to play a key role for the progress of the reaction to give the expec...

The title compound, C(16)H(12)N(2)O(4)S, was obtained by the condensation of 3-acetyl-4-hy-droxy-coumarin with thien-2-ylcarbonyl hydrazide. The pyran ring adopts a 2,4-dione tautomeric form. The benzopyran ring system is almost coplanar with the thio-phene ring [dihedral angle 0.9 (2)°]. The exocyclic C=C double bond has an E geometry. The mol-ecular conformation is stabilized by an intra-mole...

Alkynes generally serve as C2 synthons in transition-metal-catalyzed C−H annulations, herein, exploiting electron-deficient alkynes unconventional C1 synthons, the chemo- and regiospecific synthesis of functionalized 1H-imidazo[1,5-a]indol-3(2H)-ones via a redox-neutral rhodium(III)-catalyzed [4+1] annulation N-carbamoyl indoles has been achieved. This process is characterized by high regiosele...

The concept of multiple particle interference is discussed, using insights provided by the classical theory of error correcting codes. This leads to a discussion of error correction in a quantum communication channel or a quantum computer. Methods of error correction in the quantum regime are presented, and their limitations assessed. A quantum channel can recover from arbitrary decoherence of ...

The concept of multiple particle interference is discussed, using insights provided by the classical theory of error correcting codes. This leads to a discussion of error correction in a quantum communication channel or a quantum computer. Methods of error correction in the quantum regime are presented, and their limitations assessed. A quantum channel can recover from arbitrary decoherence of ...

The Ni-catalyzed reaction of aromatic amides with alkynes in the presence of KOBu t involves C-H/N-H oxidative annulation to give 1(2H)-isoquinolinones. A key to the success of the reaction is the use of a catalytic amount of strong base, such as KOBu t . The reaction shows a high functional group compatibility. The reaction with unsymmetrical alkynes, such as 1-arylalkynes, gives the correspon...