Chamomile tea is a popular beverage and herbal remedy with various health benefits, including antioxidant antimicrobial activities beneficial effects on metabolism. In this study, we investigated the inhibitory of secondary metabolites from Matricaria chamomile L. against COX2, an enzyme involved in inflammation linked to cancer development. The cytotoxicity compounds was also evaluated panel 6...

OBJECTIVE The aim of this study was to evaluate the protective effects of quercetin, rutin, hesperidin and myricetin against reactive oxygen species production with the oxidizing action of tert-butylhydroperoxide in erythrocytes from normal subjects and sickle cell anemia carriers treated with hydroxyurea. METHODS Detection of intracellular reactive oxygen species was carried out using a lipo...

Neurotransmitters are released within a millisecond after Ca2+ arrives at an active zone. However, the vesicle fusion pathway underlying this synchronous release is yet to be understood. At the center of controversy is whether hemifusion, in which outer leaflets are merged while inner leaflets are still separated, is an on-pathway or off-pathway product of Ca2+-triggered exocytosis. Using the s...

Stable free radical scavenging and antiperoxidative activities of resveratrol, a component of grapes and red wine, were evaluated and compared with some other known bioflavonoids (quercetin, catechin, kaempferol, myricetin, fisetin, ellagic acid and naringenin) widely present in the plant kingdom. Free radical scavenging activity was measured in an in vitro chemical system (DPPH assay), while f...

Aims: To find active compounds from natural ingredients that have the potential to be antivirals of SARS-CoV-2.
 Study Design: Simulation research.
 Place and Duration Study: Physics Laboratory, Department Education, Universitas Kristen Indonesia, between December 2021 August 2022.
 Methodology: The method used is a computational simulation commonly known as docking or molecular ...

Naturally occurring plant phenols such as tannic acid, quercetin, myricetin, and anthraflavic acid are known to inhibit the mutagenicity of several bay-region diol-epoxides of polycyclic aromatic hydrocarbons (PAHs). The binding of bay-region diol-epoxides of PAHs to target tissue DNA is thought to be essential for the initiation of cancer by these compounds. In this study we investigated the e...

The thioredoxin system, composed of thioredoxin reductase (TrxR), thioredoxin (Trx), and NADPH, exerts a wide range of activities in cellular redox control, antioxidant function, cell viability, and proliferation. Recently, the selenocysteine (Sec)containing mammalian TrxR has emerged as a new target for anticancer drug development because TrxR and Trx are overexpressed in many aggressive tumor...

The thioredoxin system, composed of thioredoxin reductase (TrxR), thioredoxin (Trx), and NADPH, exerts a wide range of activities in cellular redox control, antioxidant function, cell viability, and proliferation. Recently, the selenocysteine (Sec)-containing mammalian TrxR has emerged as a new target for anticancer drug development because TrxR and Trx are overexpressed in many aggressive tumo...

The amounts of three flavonoids, quercetin, kaempferol, and myricetin, in tomatoes (Solanum lycopersicum L.) and tomato-based products produced in Turkey has been determined by reversed phase high-performance liquid chromatography (RPHPLC) with UV detection. The HPLC profiles of five types of tomato, one commercial composite tomato juice, and three types of tomato paste, were obtained after aci...