Patients with inclusion body myositis demonstrate characteristic histological and electronmicroscopical abnormalities in muscle and are generally considered refractory to treatment. A patient with inclusion body myositis is described with evidence of associated autoimmune disease, who responded to steroids.

INTRODUCTION Fungal myositis is very uncommon, even in patients who are immunocompromised. Because of its rarity and a lack of clinical experience, no consensus has been reached about the best means of treating fungal myositis. To the best of our knowledge this is the first description of the treatment of fungal myositis with simultaneous intravenous and intra-lesional itraconazole. CASE PRES...

An increased incidence of malignancy in patients with poly/dermatomyositis (PM/DM) has been reported; several points remain unclear: incidence and the predictive factors for the presence of cancer and its prognosis. Aim of the study was to evaluate the frequency of malignancy among myositis patients diagnosed in our Unit in a 35 years follow-up (from 1975 to 2010). We compared epidemiological, ...

An increased incidence of malignancy in patients with poly/dermatomyositis (PM/DM) has been reported; several points remain unclear: incidence and the predictive factors for the presence of cancer and its prognosis. Aim of the study was to evaluate the frequency of malignancy among myositis patients diagnosed in our Unit in a 35 years follow-up (from 1975 to 2010). We compared epidemiological, ...

conclusions based on the findings, in case a child suffers from calf pain or gait disturbances during influenza outbreak, the possibility of bacm should be considered before performing laboratory tests, radiological examinations, or other investigations. introduction identification of the etiology of limping and gait disturbances in children necessitates accurate physical examination and histor...

To date, there are four main groups of idiopathic inflammatory myopathies (IIM): polymyositis (PM), dermatomyositis (DM), immune-mediated necrotizing myopathy (IMNM) and sporadic inclusion body myositis; based on clinical presentation and muscle pathology. Nevertheless, important phenotypical differences (either muscular and/or extra-muscular manifestations) within a group persist. In recent ye...

The aim of this study was to investigate HLA class II associations in polymyositis (PM) and dermatomyositis (DM), and to determine how these associations influence clinical and serological differences. DNA samples were obtained from 225 UK Caucasian idiopathic inflammatory myopathy patients (PM = 117, DM = 108) and compared with 537 randomly selected UK Caucasian controls. All cases had also be...

One of the most important characteristics of systemic autoimmune diseases, including idiopathic inflammatory myopathies (IIM), is the immune response to self-antigens manifested by the production of autoantibodies that recognize a variety of cytoplasmic and nuclear antigens. In the last 40 years, autoantibodies of patients with IIM have been investigated; however, some of the fundamental questi...

Using a rabbit model leading to myositis in response to exercise-induced muscle overuse, we have previously observed that TNF-alpha is involved in the exercised muscle in early developing myositis as well as both ipsiand contralaterally in the myositis which develops in response to a lengthened period of overuse. It is unknown if TNF-alpha can also be engaged contralaterally in early stages of ...

Inflammatory myopathies are the largest group of potentially treatable myopathies in children and adults. They constitute a heterogeneous group of disorders that are best classified, on the basis of distinct clinicopathologic features, in four subtypes: dermatomyositis, polymyositis, necrotizing autoimmune myositis, and inclusion-body myositis (throughout this review, I use this term to refer s...