BACKGROUND Myometrial growth and remodeling of the cytoskeleton and focal adhesions during late pregnancy may be critical aspects of myometrial activation and thus labour. Yet our understanding of these aspects is inhibited by the paucity of information concerning the components of focal adhesions in the myometrium. The focal adhesion protein hydrogen peroxide-inducible clone-5 (Hic-5) has rece...

Abnormal placental invasion encompasses penetration of chorionic villi into the myometrium within the bounds of decidua basalis. All types of abnormal placentation (AP) make difficult the placental removal after delivery [1]. Predisposing factors of AP are: placenta praevia, implantation of a gestational sac in the isthmus, repeated cesarean sections and other uterine operations, recurrent misc...

The involvement of phosphoinositide hydrolysis in the action of oxytocin and vasopressin on the uterus was investigated in gestational myometrium and decidua cells by measuring the production of inositol phosphates. Both peptides stimulated a dose related increase in all three inositol phosphates in myometrium. This may be related to the control of sarcoplasmic Ca++ levels in the myometrium. Ox...

A 38-year-old woman, gravida 3, para 1 with a history of a left salpingectomy for an ectopic pregnancy was admitted for treatment of a presumed ectopic pregnancy. Transvaginal sonography revealed an ill-defined gestational sac and fetal heart beat within the fundal myometrium adjacent to the left cornua. Laparoscopy was performed for a suspected left cornual pregnancy or intramural pregnancy. A...

Adenomyosis is a common gynecological disorder characterized by the presence of endometrial glands and stroma deep within the myometrium associated with myometrial hypertrophy and hyperplasia. Focal uterine infarction after IVF-ET in a patient with adenomyosis following biochemical pregnancy has not been previously reported, although it occurs after uterine artery embolization in order to contr...

Obstetric analgesia and anesthesia should provide optimal pain relief for the parturient with minimal risks. The local anesthetic agents are most commonly used for obstetric analgesia and anesthesia. We investigated the effect of local anesthetic agents: prilocaine, bupivacaine, ultracaine on myometrium in pregnant rats. In our study, we evaluated the effects of three local anesthetics at cumul...

Uterine metastasis from stomach carcinoma occurred in a patient who five years previously had undergone gastrectomy for gastric adenocarcinoma. CT scans showed an ill-defined lobulated low density mass in the center of the uterus. Tl-weighted MRI imaging showed that the lesion was indistinct from the myometrium; on T2-weighted imaging it showed increased signal intensity and had infiltrated the...

Adenomyosis, an estrogen-dependent inflammatory disease, is defined as the presence of endometrial glands and stroma deep within the myometrium [1]. The main clinical features of adenomyosis are dysmenorrhea and menorrhagia, which are significantly associated with peritoneal endometriosis in infertile patients at reproductive age [2,3]. The only difference between adenomyosis and endometriosis ...

Microarray technologies widen our comprehension of the major structural and metabolic transformations which affect the myometrium from the very beginning of pregnancy until parturition. The results are coherent with the mass of information which was accumulated previously, primarily on the basis of studies of selected critical factors. They highlight the activation of precise signaling pathways...

Postpartum cndometritis is often a mild to moderate infection which responds rapidly to broad spectrum antibiotics. Infrequently, a patient will develop diffuse thrombosis of the vasculature of the uterus,, thereby decreasing tissue perfusion. This results in inadequate levels of antibiotic reaching the myometrium of the uterus. A polymicrobial infection can, therefore, become well established ...