Recent data of ours demonstrate that naringenin, a flavanone derivative typical of the Citrus genus, possesses cardioprotective effects in rat hearts submitted to ischemia/reperfusion injury [Testai et al., 2013a]. These effects are due, at least in part, to a mitochondria-targeted action, since naringenin activates a mitochondrial calcium-dependent potassium channel (mitoBKCa), localized in th...

Objective(s):To examine the expressions of CD11a, CD11b, and CD11c integrins in the myocardial tissues of rats with isoproterenol-induced myocardial hypertrophy. This study also provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse it. Materials and Methods: A myocardial hypertrophy model was established by subcutaneously injecting i...

Carbon monoxide (CO) and hydrogen sulfide (H2S) are small, lipid-soluble gaseous autacoids that modulate numerous physiological processes. Historically, both gases were considered highly noxious environmental hazards having well-defined modes of toxicity: CO binds avidly to hemoglobin reducing the oxygen-carrying capacity of the protein leading to tissue hypoxia while H2S is a potent mitochondr...

Remote ischemic preconditioning (RIPC) is an intrinsic phenomenon whereby 3~4 consecutive ischemia-reperfusion cycles to a remote tissue (noncardiac) increases the tolerance of the myocardium to sustained ischemiareperfusion induced injury. Remote ischemic preconditioning induces the local release of chemical mediators which activate the sensory nerve endings to convey signals to the brain. The...

it is of value to determine the amount of viable myocardial tissue in patients suffering from chronic coronary artery disease and ventricular dysfunction. having the capability of evaluating both myocardial perfusion and function, simultaneously, myocardial scanning by ecg-gated is an appropriate method for this purpose. the aim of this study was to compare the results of myocardial perfusion a...

EVEN BEFORE the endothelium-derived relaxing factor (EDRF) was known to be nitric oxide (NO), it was recognized that it could be inactivated by the radical superoxide (O2 · ) (16). Once the EDRF was identified as NO, the chemistry underlying this phenomenon was obvious. Both NO and O2 · are radicals, and rapidly react with one another to form the strong oxidant peroxynitrite, which ultimately d...

left ventricular free wall rupture is responsible for up to 10% of in-hospital deaths following myocardial infarction. it is mainly associated with posterolateral myocardial infarction, and its antemortem diagnosis is rarely made. one of the medical complications of myocardial infarction is the rupture of the free wall, which occurs more frequently in the anterolateral wall in hypertensives, wo...

background: standard methods for the measurement of myocardial perfusion are invasive and require cardiac catheterization or the use of radioisotope dyes. the coronary sinus blood flow (csbf) is an appropriate criterion for the efficacy of myocardial perfusion. this study sought to measure csbf via transthoracic echocardiography (tte) in patients with acute myocardial infarction (ami) and to as...

Nečas J., L. Bartošíková, T. Florian, J. Klusáková, V. Suchý, E. Janoštíková, T. Bartošík, EM. B. El Naggar: Protective Effects of Flavonoid Pomiferin on Heart IschemiaReperfusion. Acta Vet. Brno 2007, 76: 363-370. The objective of the present 15-day study was to evaluate the cardioprotective potential of fl avonoid pomiferin isolated from the infructences of Maclura pomifera, Moraceae, against...