AIMS Myocardial haemorrhage is a common complication following reperfusion of ST-segment-elevation acute myocardial infarction (MI). Although its presence is clearly related to infarct size, at present it is unknown whether post-reperfusion haemorrhage affects left ventricular (LV) remodelling. Magnetic resonance imaging (MRI) can be used to identify MI, myocardial haemorrhage, and microvascula...

R eperfusion therapy for acute myocardial infarction reduces myocardial dysfunction and mortality. However, reperfusion can also injure myocardium,' and adjunctive agents have been sought to limit reperfusion injury. After laboratory reports of successful reduction in infarct size by superoxide dismutase (SOD) after ischemia and reperfusion,2-7 SOD became the first of these agents to be used in...

Coronary heart disease (CHD) is the leading cause of death globally. Following an acute coronary artery occlusion, timely myocardial reperfusion using either primary percutaneous coronary intervention (PCI) or thrombolytic therapy remains the most effective treatment strategy for reducing myocardial infarct size, preventing left ventricular remodelling, preserving left ventricular systolic func...

See article by de Groot et al. [9] (pages 315 –324) in this limitation of enzymatic infarct size [7]. Earlier, we demonissue. strated that thrombolytic therapy had no influence on the relation between infarct size estimated with aHBDH and Although the use of biochemical markers of acute left ventricular performance, indicating that coronary remyocardial infarction started in 1954 [1], their val...

Background Exposure to environmental tobacco smoke (ETS) has been epidemiologically linked to death from ischemic heart disease in nonsmokers. In this study, we evaluated the influence of 3 days, 3 weeks, and 6 weeks of ETS exposure on myocardial infarct size in a rat ischemia/reperfusion model. Methods and Results Sprague-Dawley rats exposed to ETS (four Marlboro cigarettes per 15 minutes, 6 h...

Ticagrelor (Brilinta; AstraZeneca Pharmaceuticals LP, Wilmington, DE, USA) is a direct acting, reversible, oral P2Y12 inhibitor.1) In the PLATelet inhibition and patient Outcomes (PLATO) study, compared to clopidogrel (Plavix; Bristol-Myers Squibb/Sanofi Pharmaceuticals, Bridgewater, NJ, USA), ticagrelor reduced the rate of death from vascular causes, myocardial infarction (MI), or stroke in pa...

OBJECTIVES This study tested the hypothesis that first reducing myocardial work by unloading the left ventricle (LV) with a novel intracorporeal axial flow catheter while delaying coronary reperfusion activates a myocardial protection program and reduces infarct size. BACKGROUND Ischemic heart disease is a major cause of morbidity and mortality worldwide. Primary myocardial reperfusion remain...

Purpose: To validate a computer algorithm for measuring myocardial infarct size on gadolinium enhanced MR images. The results of computer infarct sizing are studied on phase-sensitive and magnitude imaging against a histopathology reference. Materials and Methods: Validations were performed in 9 canine myocardial infarctions determined by triphenyltetrazolium chloride (TTC). The algorithm analy...

Statins have a variety of cardioprotective properties following chronic treatment. In contrast, little is known about the acute effects. Reperfusion acutely injures the heart by activation of neutrophils as well as endothelial cells. Because statins are known to influence the processes pathogenetically involved, we hypothesized that acute application of statins attenuates the sequelae of cardia...

A modified method for the measurement of total creatine phosphokinase release from venous blood samples taken four-hourly after myocardial infarction has been used in 43 patients admitted to a Coronary Care Unit. The fractional decay rate (KD) of enzyme activity has been measured by a standardized method in each patient, and accuracy of the calculation of total enzyme release has been improved ...