The purpose of any classification of leukaemia is to identify distinct biological entities which diVer in aetiology, mechanisms of leukaemogenesis, clinicopathological features, and prognosis. Since the optimal treatment for such entities diVers, their recognition is not only of scientific interest but is also essential for optimal care of patients. Acute leukaemia can be classified in many way...

The purpose of any classification of leukaemia is to identify distinct biological entities which diVer in aetiology, mechanisms of leukaemogenesis, clinicopathological features, and prognosis. Since the optimal treatment for such entities diVers, their recognition is not only of scientific interest but is also essential for optimal care of patients. Acute leukaemia can be classified in many way...

OBJECTIVE To investigate whether risks of leukaemia are related to occupational exposure to magnetic fields. METHODS The mortality experienced by a cohort of 83 997 employees of the former Central Electricity Generating Board of England and Wales was investigated for the period 1973-97. All employees were employed for at least 6 months with some employment in the period 1973-82. Computerised ...

The objective of this study was to evaluate the ecological association between indoor radon concentration and acute leukaemia incidence among children under 15 years of age in the 348 geographical units (zones d'emploi, ZE) of France between 1990 and 1998. During that period, 4015 cases were registered by the French National Registry of Childhood Leukaemia and Lymphoma. Exposure assessment was ...

Focal granulomatous giant cell reticulosis was observed in lymph nodes from treated cases of chronic lymphatic and chronic myeloid leukaemia. On the basis of clinical behaviour and histological appearance, it seems plausible that in the terminal phase of leukaemia non-neoplastic reactive reticulosis developed very similar in appearance to lymphogranulomatosis. The possible relationship between ...

Background: The glutathione S-transferase (GST) family of metabolising enzymes plays an important role in the detoxification of mutagens and carcinogens. The expression of many of these cancer susceptibility enzymes is genetically polymorphic. An increased frequency of GST-null genotypes has been associated with several malignancies. Objective: To investigate the rate of GSTT1 and GSTM1 null ge...

BACKGROUND Transforming growth factor α (TGFα) is a peptide growth factor known to be expressed in normal haemopoiesis. It is also expressed in a range of epithelial neoplasms but has not been assessed in haemopoietic malignancies. We have performed an immunohistochemical evaluation of TGFα in acute and chronic myeloid malignancies. METHODS TGFα expression was semiquantitatively assessed in 6...

Haematological disorders are getting more and more molecularly defined. This is specially so in the field of haematological malignancies. The molecular understanding has helped in fine-tuning the diagnosis, prognosis and management. The tests are becoming widely available and they enjoy both sensitivity and specificity. Following is an overview of clinical applications of molecular haematology,...

CCAAT/enhancer-binding protein alpha (C/EBPα) is an essential transcription factor for myeloid lineage commitment. Here we demonstrate that acetylation of C/EBPα at lysine residues K298 and K302, mediated at least in part by general control non-derepressible 5 (GCN5), impairs C/EBPα DNA-binding ability and modulates C/EBPα transcriptional activity. Acetylated C/EBPα is enriched in human myeloid...