Paratuberculosis (John’s disease) is infectious and chronically progressive granulomatous disease which affects domestic and wild ruminants. The causative agent is Mycobacterium avium paratuberculosis (MAP), a slow growing mycobactin dependent acid-fast bacillus. We investigated the detection and frequency of MAP in apparently healthy dromedary and Bactrian camels by insertion...

We analyzed the multilocus short sequence repeats (SSRs) of 211 and 56 isolates of Mycobacterium avium subsp. paratuberculosis and M. avium subsp. avium, respectively. The M. avium subsp. paratuberculosis isolates could be differentiated into 61 genotypes. The M. avium subsp. avium isolates showed limited diversity. These SSRs are stable and suitable for studying the molecular epidemiology of M...

The role of wildlife species in the epidemiology of paratuberculosis has been the subject of increased research efforts following the discovery of natural paratuberculosis in free-living rabbits from farms in east Scotland. This paper describes the experimental inoculation of young calves with an isolate of Mycobacterium avium subsp. paratuberculosis recovered from a free-living rabbit. After a...

We report the 4.79-Mb genome sequence of the "Indian Bison Type" biotype of Mycobacterium avium subsp. paratuberculosis strain S5, isolated from a terminally sick Jamunapari goat at the CIRG (Central Institute for Research on Goats) farm in India. This draft genome will help in studying novelties of this biotype, which is widely distributed in animals and human beings in India.

The article by Thoresen and Saxegaard (7) concerning the relationship between Mycobacterium avium and Mycobacterium paratuberculosis as determined by using the GenProbe Rapid Diagnostic System contains interesting observations, some of which are not unexpected. Because M. paratuberculosis is rather inactive biochemically and because of variability between strains, biochemical reactions appear t...

BACKGROUND Thyrotoxicosis is conceptualized as an "autoimmune" disease with no accepted infectious etiology. There are increasingly compelling data that another "autoimmune" affliction, Crohn disease, may be caused by Mycobacterium avium subspecies paratuberculosis (MAP). Like M. tb, MAP is systemic. We hypothesized that some cases of thyrotoxicosis may be initiated by a MAP infection. Because ...

B. RAMALAKSHMI , F. MUKHERJEE, A. PRASAD, V. S. BAHEKAR, S. K. RANA, G. K. SHARMA & V. A. SRINIVASAN Research and Development Center, Indian Immunologicals Limited, Hyderabad, Telangana, India; Department of Biotechnology, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India; National Dairy Development Board, R&D Laboratory, Hyderabad, Telangana, India; National Dairy Development Board, ...

The United States of America (U.S.) has made several attempts over the years to develop a producer accepted voluntary program. The focus of the U.S. Voluntary Bovine Johne's Disease Control Program (VBJDCP) is to provide producers with the tools to control Johne's disease on their farms and identify herds with a low risk for the presence of Mycobacterium avium subspecies paratuberculosis (MAP) ...

HPLC, which is gaining its place as identification tool in mycobacteriology laboratories, has been proposed to distinguish Mycobacterium paratuberculosis from Mycobacterium avium. We had reported no significant difference between M. avium and M. paratuberculosis reference strain ATCC 19698. Because of the advantages offered by such a method, we enlarged our observations to include more isolates...