Cooked food contains a variety of mutagenic heterocyclic amines. All the mutagenic heterocyclic amines tested were carcinogenic in rodents when given in the diet at 0.01-0.08%. Most of them induced cancer in the liver and in other organs. It is noteworthy that the most abundant heterocyclic amine in cooked food, 2-amino-l-methyl-6-phenylimidazo(4,5-A|pyridine, produced colon and mammary carcino...

We detect mutagens by using a special set of bacterial tester strains. We have described our test system for mutagen and carcinogen detection in a series of recent papers. I will give here only a summary of some of these results, omitting references to other work, which is credited in our original papers. A simple procedure for combining human (or rat) liver for carcinogen activation and the ba...

Metabolites from clove (Syzygium aromaticum L.) have been extensively studied for various pharmacological uses, including quercetin. Endophytic bacteria isolated plant tissues can produce similar secondary metabolites as their host plants. However, little is known about the antioxidant activity of endophytic bacterial extract leaves. Amongst potential groups, genera Bacillus widely a source ant...

in order to increase tylosin production by streptomyces fradiae, two mutagens, i. e. uv and ems (ethylmethanesulfonate) were used. death curves were plotted for these mutagens. optimum condition for obtaining mutants by uv radiation was determined by using a uv source lamp at a distance of 20 cm for 40-60 seconds. when ems was used at 4% (w/v) concentration, the best mutants were isolated after...

  For this study one species of Shyrnidae family caught along Persian Gulf in Bandarabbas city. Sphyrna lewini were transferred to the laboratory on spring 2007. The antimutagenic activity of the Methanolic and Chloroforamic extracts of muscle, liver and cartilage of Sphyrna lewini with the Ames test was investigated. The use of antimutagens and anticarcinogens in everyday life is the most effe...

The Bacillus subtilis "rec assay" test, widely used for the detection of DNA-damaging agents, was studied in detail, using an isogenic set of strains carrying different mutations in repair or recombination functions or both. recE4 and rec-45 mutations turned out to confer on the cells the highest sensitivity to known mutagens. The recE4 strain and its isogenic rec+ strain have been tested and v...

The Second International Conference on Environmental Mutagens in Human Populations was held in Prague, Czech Republic, 20-25 August 1995. The conference was organized by Radim J. Sram, William W. Au, the Czech and Slovak Society of Environmental Mutagenesis, the Czechoslovak Biological Society, the Environmental Mutagen Society, the European Environmental Mutagen Society, the International Asso...