Introduction: Aging leads to alterations not only within the complex subsystems of the neuro-musculo-skeletal system, but also in the coupling between them. Here, we studied how aging affects functional reorganizations that occur both within and between the behavioral and muscular levels, which must be coordinated to produce goal-directed movements. Using unimanual reciprocal Fitts' task, we ex...

Smooth muscle degeneration may occur in Duchenne muscular dystrophy. We measured fasting orocaecal transit time in patients with advanced Duchenne muscular dystrophy and other muscular dystrophies and in healthy controls. No significant differences were found. In contrast to reports of gastric hypomotility in Duchenne muscular dystrophy, we found no evidence of impaired small intestinal motility.

BACKGROUND Identifying translatable, non-invasive biomarkers of muscular dystrophy that better reflect the disease pathology than those currently available would aid the development of new therapies, the monitoring of disease progression and the response to therapy. OBJECTIVE The goal of this study was to evaluate a panel of serum protein biomarkers with the potential to specifically detect s...

Mdx mice develop an inflammatory myopathy characterized at different ages by myonecrosis with scattered inflammatory infiltrates followed by muscular regeneration and later persistent fibrosis. This work aimed to verify the putative anti-inflammatory role of nicotinic acetylcholine receptor (nAChR) in the mdx muscular lesion. Mitigation of myonecrosis and decreased TNFα production were accompan...

In 1971 a patient with suxamethonium-induced cardiac arrest in an unsuspected case of pseudohypertrophic muscular dystrophy was described (Genever, 1971). Suxamethonium has been implicated in several cases of muscular rigidity, hyperkalaemia and cardiac arrest and in malignant hyperpyrexia, and there is evidence that these reactions occur often when there are pre-existing muscular disorders inc...

Chronic spinal muscular atrophy of FSH type affecting a mother and her son and daughter is reported. The relevant literature is reviewed and the relation between this conditon and Kugelberg-Welander (K-W) disease is discussed. Chronic spinal muscular atrophy of FSH type is considered to be a different entity from the eponymous K-W disease. Each type of muscular dystrophy, e.g. limb-girdle, FSH,...

PURPOSE The objective of this study is to determine whether childhood muscular fitness phenotypes (strength, endurance, and power) are independently associated with adult metabolic syndrome (MetS). METHODS We conducted a longitudinal study including 737 participants who had muscular fitness measures in 1985 when age 9, 12, or 15 yr and attended follow-up in young adulthood 20 yr later when me...

BACKGROUND Cancer survivors experience muscular weakness and reduced mobility, thereby compromising quality of life. This investigation utilized moderate prescriptive exercise to improve upper- and lower-body muscular fitness, flexibility, depression and quality of life in cancer patients. PATIENTS AND METHODS One hundred and thirty-five breast and prostate cancer survivors received cancer an...

[Purpose] This study was conducted to compare and analyze influence of craniocervical flexion and suboccipitalis relaxation in cervicogenic headache patients of their cervical muscular fatigue, tone, and headache intensity. [Subjects and Methods] 30 patients with cervicogenic headache were selected and 10 subjects per group were randomly assigned to control group, craniocervical flexion exercis...