Background. Mupirocin ointment is often used to attempt eradication of colonization with methicillin-resistant Staphylococcus aureus (MRSA). However, mupirocin resistance, particularly among community-onset MRSA strains, has been increasing. This study sought to describe the prevalence and epidemiology of mupirocin resistance among community-dwelling subjects and their colonized household membe...

In a prospective study, 218 cardiothoracic patients, in whom 'Abbocath-T' cannulae had been inserted preoperatively into the internal jugular vein, were randomized to receive skin preparation of the insertion site with tincture of iodine (108 controls) or tincture of iodine followed by application of sterile 2% calcium mupirocin ointment (110 test patients). Cannulae were usually removed within...

Mupirocin has been widely used for the clearance of nasal methicillin-resistant Staphylococcus aureus (MRSA) carriage during outbreaks, but no placebo-controlled trial has evaluated its value for eradicating MRSA carriage at multiple body sites in settings where MRSA is not epidemic. In a 1,500-bed teaching hospital with endemic MRSA, 102 patients colonized with MRSA were randomized into a doub...

Abstract: Introduction: Biofilm is a complex structure of microbiome having different bacterial colonies or single type cells in group, adhere to the surface produce infections. Nanoparticles (NPs) are widely used technological fields especially medicine because their antibacterial properties. Silver nanoparticles (AgNPs) possess antimicrobial and antibiofilm property against various microbial ...

OBJECTIVES Both low-level mupirocin resistance (LMR) and high-level mupirocin resistance (HMR) have been identified. The aim of this study was to determine the epidemiology of LMR and HMR in MRSA isolates at five hospitals that have used mupirocin for targeted decolonization as part of successful institutional control programmes. METHODS All MRSA identified in three microbiology laboratories ...

The antimicrobial activities of tetracycline, mupirocin, and fusidic acid are tested in combination with Epicatechin Gallate (ECG), and Ethyl Gallate (EG) using 2 Methicillin resistant (MRSA) and 2 Methicillin sensitive (MSSA) strains of Staphylococcus aureus. Sub-inhibitory concentration of EG at 256 mg l-1 is found to be synergistic when used in combination with tetracycline, mupirocin, and f...

Catheter exit site/tunnel infections are a major cause of S. aureus peritonitis in peritoneal dialysis (PD) patients. Hence, the prevention of ESI and tunnel infection due to S. aureus is important. A number of studies have reported that the application of mupirocin ointment intranasally or to the catheter exit site prophylactically, reduces S. aureus ESI/tunnel infection and peritonitis when c...

OBJECTIVE To assess the cost-effectiveness of perioperative intranasal application of mupirocin calcium ointment in cardiothoracic surgery. DESIGN Cost-effectiveness analysis based on results of an intervention study with historical controls. SETTING University Hospital Rotterdam, a tertiary referral center for cardiac and pulmonary surgery. PATIENTS Consecutive patients undergoing cardio...

Mupirocin is used for eradicating methicillin-resistant S. aureus (MRSA) in nasal colonization. A plasmid-borne gene, mupA, is associated with high-level mupirocin resistance. Despite the fact that, among all MRSA from a tertiary care center in the German state of Saxony, the prevalence of mupA, encoding high-level mupirocin resistance, was approximately 1% over a 15-year period from 2000-2015,...