نتایج جستجو برای: multisubstituted pyrroles
تعداد نتایج: 2001 فیلتر نتایج به سال:
An iron-catalysed cascade synthesis of pyrroles from nitroarenes was developed. The homogeneous catalyst shows remarkable activity at room temperature. Its wide functional group tolerance enables late-stage functionalization drug(-like) molecules.
The palladium(0)-catalyzed dearomative arylation of pyrroles has been accomplished to afford the spironaphthalenepyrrole derivatives in good to excellent yields.
We report the unusual formation of thiaisoporphyrins containing bridging sp(3)meso carbon between two pyrroles when 21-thiaporphyrins were reacted with PhBCl2 in dry toluene at reflux temperature.
A sequential Pd-mediated multi-component reaction followed by Suzuki or Heck or Sonogashira coupling in a single pot has been developed for the synthesis of functionalized pyrroles as potential inhibitors of PDE4.
N-Alkyl pyrroles are obtained in a single step from 4-hydroxyproline and aldehydes in just 15 min under microwave irradiation.
BACKGROUND Trifluoromethylated alkene scaffolds are known as useful structural motifs in pharmaceuticals and agrochemicals as well as functional organic materials. But reported synthetic methods usually require multiple synthetic steps and/or exhibit limitation with respect to access to tri- and tetrasubstituted CF3-alkenes. Thus development of new methodologies for facile construction of Calke...
Magnetically induced current densities and strengths of currents passing through selected bonds have been calculated for monophosphorous [28]hexaphyrin ((PO)[28]hp) and for bisphosphorous [30]hexaphyrin ((PO)(2)[30]hp) at the density functional theory level using our gauge-including magnetically induced current (GIMIC) approach. The current-density calculations yield quantitative information ab...
The sterically encumbered pyrrolyl KPyr(tBu2) (1-K, Pyr(tBu2) = 2,5-(Me3C)2C4H2N) reacts with PCl3, (iPr)2PCl and Ph2PCl exclusively at the C3-position to yield a series of phosphine-substituted pyrroles HPyr(tBu2R) (R = PCl2 (2-H), (iPr)2P (4-H) and Ph2P (5-H)). Pyrrole 2-H can further be functionalized with MeLi (3 equiv.) to yield LiPyr(tBu2PMe2) (3-Li). The coordination chemistry of these p...
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