The syndrome of multiple organ failure has been recognised as a distinc t entity since the 1970s, and is the leading cause of mortality in intensive care1. It was subsequently appreciated that patients develop a spectrum of organ dysfunction which may or may not require pharmacological (eg inotropic) or mechanical (eg ventilation) support. This led to the coining of a new syndrome, multi-organ ...

OBJECTIVES The purpose of this study was to test whether mitochondrial dysfunction is causative of sepsis sequelae, a mouse model of peritonitis sepsis induced by cecal ligation and perforation. Inhibition of mitochondrial permeability transition was achieved by means of pharmacological drugs and overexpression of the antiapoptotic protein B-cell leukemia (Bcl)-2. BACKGROUND Sepsis is the lea...

Multiple organ failure (MOF) is a common cause of death in intensive care unit (ICU) patients [1]. But what are the mechanisms underlying the development of MOF? Why, when we can support many of the individual organs, e.g., the kidneys with extracorporeal renal support, the lungs with mechanical ventilation, etc., do we all too often end up withholding/withdrawing these life-supporting therapie...

sepsis is a systemic inflammatory response to infection. sepsis, which can lead to severe sepsis, septic shock, and multiple organ dysfunction syndrome, is an important cause of mortality. pathogenesis is extremely complex. in recent years, cell hypoxia caused by mitochondrial dysfunction has become a hot research field. sepsis damages the structure and function of mitochondria,conversely, mito...

1 Therapeutic interventions aimed at preventing MODS The terms multiple organ failure syndrome (MOFS), multiple systems organ failure (MSOF) and, most recently, multiple organ dysfunction syndrome (MODS) have all been used to describe ‘irreversible shock’ and organ failure. Summarised the causes of irreversible shock are: (1) Haemorrhage uncomplicated by gross trauma; (2) burns; (3) trauma to l...

Shock is a pathological condition characterized by imbalance between oxygen demand and supply. Irrespective of the cause, shock leads to state energy failure due decrease in adenosine triphosphate (ATP) production, creation lactic acidosis, as consequence, multiple organ dysfunction [1].