Background: Meningiomas are slow-growing neoplasms, accounting for 20% of all primary intracranial neoplasms and 25% intraspinal tumors. Atypical anaplastic meningiomas infrequent, representing fewer than 5% meningiomas. Unusually, they can show aggressive behavior, extracranial metastases extremely rare, approximately 0.1% reported cases. Case Description: Fifty-six-year-old male patient diagn...

OBJECTIVE To investigate the potential involvements of E-cadherin and beta-catenin in meningioma. METHODS Immunohistochemistry staining was performed on samples from patients with meningioma. The results were graded according to the positive ratio and intensity of tissue immunoreactivity. The expression of E-cadherin and beta-catenin in meningioma was analyzed by its relationship with WHO2007...

  Background and Objective: Histological grading has prognostic and therapeutic implications in meningioma. However, histological criteria are sometimes not fulfilled to predict the biological behavior of meningiomas. P63 gene is a novel P53 family member, known as tumor suppressor factor, with multiple isoforms and shows high expression in many normal and neoplastic human tissues. In this stu...

In most series of neoplasms of the spinal canal, spinal cord and its leptomeninges, the incidence of meningioma group comprises approximately 25%. The incidence of multiple meningiomas is small when compared with the frequency of its single occurrence. In the majority of cases, their multiplicity is intracranial and spinal. Multiple meningiomas confined exclusively to the spinal canal are extre...

This case report illustrates a patient who was found to have multiple sites of angioblastic meningiomas in the spinal and intracranial subarachnoid space 15 to 18 years after resection of an angioblastic meningioma from the upper cervical canal. The presence of the multiple sites of tumor could represent either multicentric origin or subarachnoid seeding.

A difficult diagnostic problem may be caused by the presence of multiple pulmonary nodules on a chest radiograph. The differential diagnosis includes infection, primary or metastatic tumour (benign or malignant), and the expression of systemic disease such as rheumatoid arthritis and sarcoidosis. This case report describes a patient with multiple lung tumours considered to be due to metastatic ...

Fleury Diagnostic Center, Section of Radiology, São Paulo SP, Brazil; Santa Casa de Misericórdia de São Paulo, Section of Radiology, São Paulo SP Brazil; Santa Casa de Misericórdia de São Paulo, Section of Neurology, São Paulo SP, Brazil; Santa Casa de Misericórdia de São Paulo, Section of Neurosurgery, São Paulo SP, Brazil; Santa Casa de Misericórdia de São Paulo, Section of Pathology, São Pau...

Primary ectopic meningiomas are extremely rare tumors of controversial origin and they are usually limited to the head and neck region. Its occurrence at the mediastinum is even rarer. There has not been any official report regarding primary mediastinal malignant meningioma until today. Because of its rarity and potential value, we report here a case of primary mediastinal malignant meningioma,...