In recent years there have been advances in the biology of renal malformations. Our focus is on human disease, but we will use animal paradigms when relevant. The mammalian kidney derives from two metanephric components (1-5): ureteric bud, which forms collecting ducts and uroepithelium, and renal mesenchyme, which forms nephrons. The human metanephros appears at 5 wk gestation, and glomeruli f...

*Common type of cystic disease of the kidney Introduction Cystic diseases of the kidney are common lesions worldwide.1–5 They are broadly divided into genetic and nongenetic cysts. A renal cyst is a fluid-filled sac arising from dilatation in any part of the nephrons or collecting ducts. The cysts may eventually separate from the nephrons or ducts and continue to enlarge. Although most are simp...

Benign multicystic peritoneal mesothelioma (BMPM), also known as multilocular peritoneal inclusion cyst, is a rare tumour that occurs mainly in women at their reproductive age. The aetiology and pathogenesis are controversial. It originates from any abdominal peritoneal or pleural surface. The biological behaviour of BMPM is usually clinically benign. Here we present a case report of BMPM from ...

Multicystic dysplastic kidney (MCDK) is a congenital anomaly as the result of abnormal interaction between the ureteric bud and metanephric mesenchyme. Unilateral MCDK can be associated with other anomalies of the genitourinary tract. Relatively rare associated anomaly is the presence of ipsilateral refluxing blind megaureter. The patient reported herein is a 23-years-old woman with involuted M...

Although renal abnormalities have been described in children with Alagille's syndrome, cystic kidney disease has not often been documented, and then usually only at necropsy. Three children with Alagille's syndrome are described, in two of whom a unilateral multicystic dysplastic kidney was detected by prenatal ultrasound; in the other, a solitary cortical cyst was found later in childhood. All...

BACKGROUND Renal cystic diseases are important causes of chronic kidney disease (CKD). OBJECTIVES We report the pattern of renal cystic disease in children and evaluate the outcome of children with multicystic dysplastic kidney (MCDK). PATIENTS AND METHODS Retrospective study of all children with cystic kidney diseases at King Abdulaziz University hospital from 2006 to 2014. RESULTS Total...

Etiology of multicystic dysplastic kidney (MCDK) remains unknown. Not all cases are associated with obstruction. We compared by immunohistochemistry 17 cases of MCDK (10 cases with and seven without obstruction) to 17 controls and 20 fetal kidneys. TGF-β was negative in obstructive MCDKs and positive in nonobstructive MCDK. IGF2 was overexpressed in obstructive and underexpressed in nonobstruct...

BACKGROUND Multicystic nephroma is an uncommon, non-familial renal neoplasm that is usually benign. About 200 cases of this lesion have been described in the literature. CASE PRESENTATION We report on a Sudanese child who presented at the age of two and a half years with an abdominal mass, clinical and radiological features favored the diagnosis of hydatid cyst which is endemic in this Africa...

Introduction We evaluated the applicability of laparoscopic nephrectomy in the treatment of multicystic dysplastic kidney (MCDK) in children, including procedures performed by resident physicians or trainees in surgical urology. Methods We retrospectively evaluated the medical records of 20 children with MCDK who underwent laparoscopic nephrectomy over a six-year period. Data collected included...