The effect of rebamipide, a mucosal protective drug, on small intestinal mucosal injury caused by indomethacin was examined using a rat model. Indomethacin administration (10 mg/kg, p.o.) induced intestinal mucosal injury was accompanied by an increase in the numbers of intestinal bacteria particularly Enterobacteriaceae in the jejunum and ileum. Rebamipide (30 and 100 mg/kg, p.o., given 5 time...

BACKGROUND & AIMS The study and management of reflux esophagitis require an endoscopic classification system founded on esophageal lesions that can be reproducibly identified. The aim of this study was to investigate interobserver agreement for the identification of endoscopic lesions typical of reflux esophagitis. METHODS Paired comparisons of observers' descriptions were obtained. Seventeen...

Alterations in the intestinal microbiota have been suggested as an etiological factor in the pathogenesis of irritable bowel syndrome (IBS). This study used a molecular fingerprinting technique to compare the composition and biodiversity of the microbiota within fecal and mucosal niches between patients with diarrhea-predominant IBS (D-IBS) and healthy controls. Terminal-restriction fragment (T...

Mucosal vaccination offers great advantage for inducing protective immune response to prevent viral transmission and dissemination. Here, we report our findings of a head-to-head comparison of two viral vectors modified vaccinia Ankara (MVA) and a novel replication-competent modified vaccinia Tian Tan (MVTT) for inducing neutralizing antibodies (Nabs) via intramuscular and mucosal vaccinations ...

The quantitative detection of viable pathogen load is an important tool in determining the degree of infection in animals and contamination of foodstuffs. Current conventional culture methods are limited in their ability to determine these levels in Mycobacterium avium subspecies paratuberculosis (MAP) due to slow growth, clumping and low recoverability issues. The principle goal of this study ...

BACKGROUND Evaluation of the prolonged impact of weaning diet on ileal mucosa bacteria and during periods of reduced and improved growth was conducted using 454 pyrosequencing. METHODOLOGY/PRINCIPAL FINDINGS Weaned pigs were fed HIGH or LOW complexity diets, with or without antibiotics, for 6 weeks, followed by a common grower diet. Pigs were killed at 2 (n = 4 or 5) and 8 (n = 6) weeks post-...

Aim : to identify risk factors for neoplasms recurrence removed by endoscopic mucosal resection (EMR). Patients and methods the single-center retrospective observational study included 207 patients with 260 benign colon neoplasms. There were 95 (45.9%) males 112 (54.1%) females. The median age of was 67 (27-80) years. results obtained assessed using following criteria: morbidity rate, complicat...

By applying tension asymmetries in a finite-element model of vocal fold vibration, a variety of modes of phonation were simulated. The biophysical model incorporated tissue mechanics, glottal aerodynamics, and acoustics of the vocal tract. For simplicity and speed, glottal aerodynamics were modeled with a modified Bernoulli equation. Vocal tract acoustics were modeled using a wave reflection an...