OBJECTIVE The aim of this study was to determine the in vitro anti-inflammatory activities of solvent fractions from Chlorella vulgaris by inhibiting the production of pro-inflammatory mediators and cytokines. METHODS Methanolic extracts (80%) of C. vulgaris were prepared and partitioned with solvents of increasing polarity viz., n-hexane, chloroform, ethanol, and water. Various concentration...

A study was undertaken to compare the proliferative index of macroschizont-infected lymphoblastoid cells of two Indian strains [Izatnagar (IZT) and Parbhani (PBN)] of Theileria annulata by an in vitro MTT [3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide], colorimetric assay. Culture conditions were standardized to define the optimal cell concentration in 96-well microculture plat...

PURPOSE The survival of retinal ganglion cells (RGCs) is a hallmark of many optic neurodegenerative diseases such as glaucoma. YC-1, a potential anticancer drug, is known to be able to decrease the stability and protein expression of hypoxia-inducible factor (HIF)-1α that is triggered by hypoxia and related to RGC survival. We hypothesized that YC-1 may alter RGC cell viability through the down...

Cervical cancer is one of the most common suffered in women. Chemotherapy usage often causes physical and psychological side effects patients. This study aims to determine antioxidant cytotoxic ethyl acetate fraction melinjo seeds (Gnetum gnemon L.) on HeLa cervical cells through vitro silico assays. Melinjo seed was extracted by maceration using ethanol 70% fractionated with obtain Ethyl Aceta...

BACKGROUND Homonoia riparia is a plant, which is widely used in the indigenous system of medicine for the treatment of urolithiasis, renal disorders and inflammatory conditions. This is the first report on the antioxidant and nephroprotective activities of whole plant of H. riparia. OBJECTIVE The present study aims at investigating the in vitro antioxidant and nephroprotective activity of the...

Treatment for cancer is often challenging and various interventions may have detrimental effects. Due to this, the development of less harmful alternatives such as herbal medicine essential. The present study aims determine leaf phytoconstituents bioactivities Mallotus cumingii Müll.Arg against cells through utilization MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assa...

Matrine is one of the main active components that is extracted from the dry roots of Sophora flavescens. The compound has potent antitumor activity in various cancer cell lines. However, the anticancer activity of matrine in colon cancer cells remains unclear. The purpose of the present study was to investigate the effects of matrine on the growth of human colon cancer cells and the expression ...

Moringa oleifera leaves extracted with methanol and dichloromethane were screened for antioxidant activity. The in vitro cancer antiproliferative and chemopreventive properties were also investigated. Radical scavenging assays with 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2 ́-azino-bis 3ethylbenzothiazoline-6-sulfonic acid (ABTS) were used to determine the antioxidant activity. The antiprolif...

Introduction Untreated dental decay poses a significant oral health challenge, leading to pain, tooth loss, and infections. Fluoride varnishes are in prolonged contact with the surface this prevents decay. However, limited research has been conducted regarding cytotoxicity cytocompatibility of on cells. Recent studies have shed light cytotoxic effect these human fibroblast Material Methods The ...

The most effective drugs based on the type of cancer are chosen for chemotherapy. Tumor cells can be targeted at the DNA, RNA or protein level, and most of the classical anticancer drugs interact with tumor DNA in a time-dependent manner or a concentration-dependent manner. However, it has been unclear to date whether a combination therapy is carried out by using exact classification. Thus it i...