Multiple system atrophy (MSA) is a sporadic neurodegenerative disease that is pathologically characterized by α‑synuclein positive glial cytoplasmic inclusions in oligodendrocytes. The clinical diagnosis of MSA is often challenging as there are no established biomarkers and diagnoses are now based on clinical findings alone. At present, the etiology and pathogenesis of MSA are unclear. It has b...

Modern Standard Arabic (MSA) has a wealth of natural language processing (NLP) tools and resources. In comparison, resources for dialectal Arabic (DA), the unstandardized spoken varieties of Arabic, are still lacking. We present ELISSA, a machine translation (MT) system for DA to MSA. ELISSA employs a rule-based approach that relies on morphological analysis, transfer rules and dictionaries in ...

Multiple Sequence Alignment (MSA) is a fundamental analysis method used in bioinformatics and many comparative genomic applications. The time to compute an optimal MSA grows exponentially with respect to the number of sequences. Consequently, producing timely results on large problems requires more e cient algorithms and the use of parallel computing resources. In response to a growing volume o...

To determine whether the nocturnal decrease in arginine vasopressin (AVP) secretion into the plasma, found in a patient with multiple system atrophy (MSA) reported previously, is a usual finding in MSA, the plasma AVP concentrations in 13 patients with MSA were measured every 4 hours during a 24 hour period. The plasma AVP concentrations in these patients showed significant daily variations and...

Approximately 50 ka, one or more subgroups of modern humans expanded from Africa to populate the rest of the world. Significant behavioral change accompanied this expansion, and archaeologists commonly seek its roots in the African Middle Stone Age (MSA; ∼200 to ∼50 ka). Easily recognizable art objects and "jewelry" become common only in sites that postdate the MSA in Africa and Eurasia, but so...

OBJECTIVE We performed (1)H-MR spectroscopy ((1)H-MRS) on multiple brain regions to determine the metabolite pattern and diagnostic utility of (1)H-MRS in multiple system atrophy (MSA). METHODS Examining single voxels at 3.0 T, we studied metabolic findings of the putamen, pontine base, and cerebral white matter in 24 MSA patients (predominant cerebellar ataxia (MSA-C), n = 13), parkinsonism ...

BACKGROUND Although cognitive impairment is not a consistent feature of multiple system atrophy (MSA), increasing evidence suggests that cognitive impairment is common in MSA with predominant parkinsonism (MSA-P). It is assumed that the cognitive impairment in MSA-P is caused by the striatal dysfunction and disruption of striatofrontal connections. The aim of this study was to evaluate the rela...

several elegant methodological features, including the use of clinically accepted diagnostic criteria, distinction between “possible” and “probable” diagnostic levels of certitude, systematic use of the Unified Parkinson’s Disease Rating Scale (UPDRS) across diseases and probes of global vs. frontal cognitive function. These features allow inferences to be drawn about the impacts of disease sev...

Objectives—Urinary dysfunction is a prominent autonomic feature in Parkinson’s disease (PD) and multiple system atrophy (MSA), which is not only troublesome but also a cause of morbidity in these disorders. Recent advances in investigative uroneurology oVer a better insight into the underlying pathophysiology and appropriate management for urinary dysfunction. Methods—twenty one patients with P...

BACKGROUND Despite several lines of evidence from preclinical and post-mortem studies suggesting that inflammation is involved in Multiple System Atrophy (MSA), no previous studies have measured peripheral indices of inflammation in MSA patients. METHODS We measured C-reactive protein, interleukin (IL)-6, soluble IL-2 receptor and tumor necrosis factor (TNF)-α in blood samples from MSA patien...