leptin is secreted mainly by fat, which is involved in energy metabolism and reproduction. leptin and itsreceptor (ob-r) have been detected in human spermatozoa and testis, thus it can be concluded leptin involves in male physiology. the goal of this study was determination of the presence of leptin receptor mrna in the ram testis, epididymis and spermatozoa by reverse transcription polymerase ...

objective: prostate cancer antigen 3 (pca3) and microrna-141 (mir-141) are emerging molecules in prostate cancer (pca) pathogenesis and have been shown to be involved in androgen signaling. in this original research, we designed an experimental cell model with androgen-sensitive lncap cells to comparatively assess the extent of androgen responsiveness of pca3-mrna and mir-141 along with prostat...

The effects of chronic stress and glucocorticoids receptor antagonist (RU486) on expression of melanocortin 4 receptor (MC4R) mRNA in arcuate nucleus (ARC) of male rats were evaluated. In this study, adult male Sprague Dawley rats were placed into four groups (n=6/group) stress, RU486, stress/RU486, and control groups. In stress group, the rats were restrained, 1 h/day, for 12 days. In RU486 gr...

1 This research is supported by State of Georgia's Yamacraw Research Contract #BLA42, #CLH49 and #DLN01. ABSTRACT We have developed a generic “Listener” module in Java called SyDListener, or “System on Mobile Devices (SyD) Listener Module”. It is designed and implemented as part of a software package we developed that is called SyDKernel. SyDKernel is a middleware package that can be used in de...

A few readers of my last two columns may have suspected that something was afoot. Why, they might ask, does he suddenly produce not one, but two confessions? After shamefacedly exposing his tendency to consider book theft as a way of acquiring knowledge and trying to reverse the hint of plagiarism in his works by suggesting that it was the other way around, we might expect anything. Well, the e...

elevated expression of the drug efflux transporter abcg2 seems to correlate with multidrug resistance of cancer cells. specific cox-2 inhibitor celecoxib has been shown to enhance the sensitivity of cancer cells to anticancer drugs. to clarify whether abcg2 inhibition is involved in the sensitizing effect of celecoxib, we investigated whether the expression of abcg2 in breast cancer cell lines ...

Leptin is secreted mainly by fat, which is involved in energy metabolism and reproduction. Leptin and itsreceptor (Ob-R) have been detected in human spermatozoa and testis, thus it can be concluded leptin involves in male physiology. The goal of this study was determination of the presence of leptin receptor mRNA in the ram testis, epididymis and spermatozoa by reverse transcription polymerase ...

Background: Interleukin-17 (IL-17), as a potent proinflammatory cytokine, has a critical role in post liver transplant outcomes. However, there is not much information about the effects of IL-17 cytokine on acute liver rejection. Objective: To evaluate the role of IL-17 in post-liver transplant acute rejection. Methods: Ninety seven adult liver transplant patients who enrolled in this cross sec...