Because magnetic resonance imaging (MRI) contrast agents play a vital role in diagnosing diseases, demand for new MRI contrast agents, with an enhanced sensitivity and advanced functionalities, is very high. During the past decade, various inorganic nanoparticles have been used as MRI contrast agents due to their unique properties, such as large surface area, easy surface functionalization, exc...

The overarching aim of the project is to develop a noninvasive biopsy system that can image the molecular signatures of a disease in its in vivo native state, in 3D, and throughout the progression of the disease. A focused ultrasound-based drug delivery system will be used to noninvasively and locally deliver normally impermeable targeted MRI contrast agents across the capillaries of a target d...

Contrast agents are of great importance in clinical applications of Magnetic Resonance Imaging (MRI) to improve the contrast of internal body structures and to obtain tissue-specific image. However, current approved contrast agents still have limitations including low relaxivity, low specificity and uncontrolled blood circulation time, which motivated researchers to develop novel contrast agent...

Abstract The NMR relaxivities of the decatungstolanthanoate core‐shell nanoparticles, prepared by encapsulating [Ln(W 5 O 18 ) 2 ] 9− polyoxometalates (LnPOM) within amorphous silica shells (K 9 ]@SiO ), were studied along Ln series. relaxivity GdPOM is slightly higher than for Gd‐DTPA due to second‐sphere relaxation effects, but values other paramagnetic LnPOMs are much smaller short T 1e thei...