Experimental and clinical studies have reported phenomena of long-range fluid flow in interstitial space. However, their behaviours functions are yet to be addressed. Image on stream vivo ...

Contrast agents are of great importance in clinical applications of Magnetic Resonance Imaging (MRI) to improve the contrast of internal body structures and to obtain tissue-specific image. However, current approved contrast agents still have limitations including low relaxivity, low specificity and uncontrolled blood circulation time, which motivated researchers to develop novel contrast agent...

It is not known whether administration of contrast agent via retro-orbital injection or the tail vein route affects the efficiency of dynamic contrast-enhanced magnetic resonance imaging (MRI). Therefore, we compared the effects of retro-orbital and tail vein injection on the kinetics of the contrast agent used for MRI in mice. The same group of nine healthy female mice received contrast agent ...

Introduction: Application of Gadolinium (Gd) based MRI contrast agents is limited in patients with severe renal disease or following liver transplant due to association of a recently reported incurable and nonmitigable Nephrogenic Systemic Fibrosis (NSF) disease. These limitations give rise to choose Mn (having 5 unpaired electrons) as a better paramagnetic label to obtain MRI contrast agents. ...

two new potential magnetic resonance imaging contrast agents, gd-hematoporphyrin (gd-h) and gd-tetra-carboranylmethoxyphenyl-porphyrin (gd tcp), were synthesized and applied to nude mice with human melanoma (mm 138) xenografts. these agents showed a high relaxivity because of their greater potential to coordinate water molecules. the reduction of t1 relaxation times of 16 and 21% was observed i...

Introduction: Breast cancer is the most common cancer in women and is the second leading cause of cancer death (after lung cancer) in people throughout the world. Today, MRI is being used because of the limitations of x-ray mammography to detect breast cancer. Non-contrast sequences were associated to CE sequences in a breast MRI protocol for the sake of appraising morphologic ...