background: the frequency of pyruvate kinase (pk) deficiency, an autosomal recessive defect, is approximately 3 per 10,000 individuals in shiraz and surrounding areas, and is increased due to high consanguinity marriage frequency. the purpose of this study is to obtain data on the frequency and spectrum of gene mutation of pk in newborns, from shiraz and surrounding areas. materials and methods...

Design of blood compatible surfaces is obligatory to minimize platelet surface interactions and improve the thromboresistance of foreign surfaces when they are utilized as biomaterials particularly for blood contacting devices. Pure metallocene polyethylene (mPE) and nitric acid (HNO3) treated mPE antithrombogenicity and hydrophilicity were investigated. The contact angle of the mPE treated wit...

The problem of Most Probable Explanation (MPE) arises in the scenario of probabilistic inference: finding an assignment to all variables that has the maximum likelihood given some evidence. We consider the more general CNF-based MPE problem, where each literal in a CNF-formula is associated with a weight. We describe reductions between MPE and weighted MAX-SAT, and show that both can be solved ...

BACKGROUND Myelomatous pleural effusion (MPE) is rare in myeloma patients. We present a consecutive series of patients with MPE in a single institution. METHODS We retrospectively reviewed the medical records of 19 patients diagnosed with MPE between 1989 and 2008 at the Asan Medical Center. Diagnoses were confirmed by cytologic identification of malignant plasma cells in the pleural fluid. ...

We assessed pharmacokinetic (PK) parameters of reduced dose lopinavir/ritonavir (LPV/r) and compared generic and branded tablets. Twenty HIV-infected patients using protease inhibitors with HIV RNA <50 copies per milliliter were randomized to generic or branded LPV/r 200/50mg twice daily (BID). At week 2, PK-sampling was performed. Patients crossed over to the other arm until week 12, with anot...

In veterinary drug development procedures, pharmacokinetic (PK) and pharmacodynamic (PD) data have generally been established in separate, parallel studies to assist in the design of dosage schedules for subsequent evaluation in clinical trials. This review introduces the concept of PK/PD modelling, an approach in which PK and PD data are generated in the same study, and used to derive numerica...

Mixed-effects population models 11 were fitted to the log-transformed propofol blood and plasma concentration versus time data. The program NONMEM version 6 12 was used. Models were fitted using the first order conditional estimation method with interaction between the interindividual error terms (ETAs) and the random residual error term allowed. Random residual error was described using an add...

Accurate quantitative diagnosis of free-conducting particle faults plays an important role in improving the reliability gas insulated line (GIL) system. However, existing fault methods cannot accurately identify with different quantities and sizes. Motivated by this, this paper proposes a novel method based on vibration signals, which integrates variational mode decomposition (VMD), self-adapti...