Background Spermatogenesis is a process in which the gametes are produced. Dysfunction in any of part of the process could result in infertility. Tribulus terrestris is a flowering plant which traditionally is used to sexual instinct. Reports indicate that this plant could elevate blood levels testosterone and enhance libido. MaterialsAndMethods In this experimental study, twenty six mature inb...

Background: It is demonstrated that c-Kit( receptor of stem cell factor) mRNA is expressed in late 2-cell stage to the expanded and hatched blastocyst and the stem cell factor (SCF) transcript is detected in the oviduct and uterus. The aim of this study was to investigate the effect of different doses of SCF on mouse 2-cell embryo development in vitro. Materials and Methods: 4-6 weeks old femal...

Objective: Indomethacin is a non-selective cyclooxygenase (COX) inhibitor that is commonly administered to extremely low gestational age neonates for symptomatic patent ductus arteriosus. It suppresses prostaglandins which modulate growth and secretion of various hormones. We examined the hypothesis that early postnatal administration of Indomethacin may influence growth and development of test...

Background: The fibroblast growth factors (FGF-4) are a group of heparin-binding single chain polypeptides that play a pivotal role in development, cell growth, tissue repairing and transformation. The aim of this study is to improve development and maturation outcome of vitrified mouse pre-antral follicle by adding of fibroblast growth factor (FGF) into medium culture. Materials and Methods: P...

Background: Nicotine can induce sub fertility and infertility in females. The aim of this study was to determine the effect of nicotine on follicular cells proliferative activity in mouse ovary. Materials and Methods: Female adult NMRI mice were divided into two groups. Animals in control group received vehicle, however in experimental group, animals were treated with 0.4mg/kg of nicotine for 1...

Background: Physiological effects of obesity are increasingly common in women of reproductive age and are associated with infertility. Obese women have dysfunction in hypothalamic-pituitary-ovarian axis, menstrual cycle and are up to three times more likely to have decreased oligo-/anovulation. The purpose of present study was to evaluate the high fat diet on IVM and IVF outcomes in mouse. Mate...

Background The aim of this study was to evaluate the effect of L-carnitine as an antioxidant on transplantation of ovarian tissue. MaterialsAndMethods Ovaries from 6-week old mice were grafted into back muscle. Transplanted ovaries were divided into three groups. 150 mg/Kg LC (solved in normal saline) was injected intraperitoneally one hour before surgical operation and repeated one other day u...

Background: Mammalian sperm are not ready to fertilize oocyte immediately after ejaculation. Sperm achieve this ability after undergoing the processes of capacitation and hyperactivation. Hyperactivation refers to a change in the motility pattern of the sperm. Pharmacological reagents and physical-mechanical forces have been used in sperm from a variety of species. Hydrostatic pressure is a cru...

background: cancer immunotherapy attempts to stimulate the immune system to reject and destroy tumors and is one of the cancer treatment strategies. recently, interluekin36 (il36) has been used as immunotherapeutic agents in cancer gene therapy. present study investigated that the il36 gene therapy effects on the regression of tumor masses in mouse model. aim of this study is determination of t...

Background: Cobalt (Co) is an essential trace element for mammals required for the synthesis of vitamin B12. It is not a cumulative toxin but chronic exposure induces negative effects on the organism. It was proven that cobalt passes via placenta appearing in the fetal blood and amniotic fluid and it is shown to possess an embryotoxic effect. Also, chromium (Cr) is recognized as a trace element...