Over four hundred alkaloids in amphibian skin have been detected and structures from twenty different classes have been elucidated. These include batrachotoxins, histrionicotoxins, pumiliotoxins, epibatidine, pyrrolidines, piperidines, decahydroquinolines, pyrrolizidines, indolizidines, quinolizidines and tricyclic gephyrotoxins, pyrrolizidine oximes, pseudophrynamines, coccinellines and cyclop...

Three new pavine N-oxide alkaloids, (-)-isocaryachine-N-oxide B, (+)-caryachine-N-oxide, (-)-caryachine-N-oxide, and a new isoquinoline alkaloid, 6,7-methylenedioxy-N-methylisoquinoline together with 11 known alkaloids were isolated and characterized from the stem bark of Cryptocarya chinensis. The structures of the isolated compounds were determined by spectral methods. The stereochemistry of ...

Background & Aim: A. belladonna (family: Solanaceae) is one of important pharmaceutical plants which contain tropane ‎alkaloids. Tropane alkaloids are distinct group of secondary metabolites of the ‎Solanaceae family.  The most important alkaloids of A. belladonna are atropine and hyoscine that are used extensively because of their medicinal properties. There...

the pyrrolizidine alkaloids (pas) are a group of chemicals found in a variety of plant species throughout the world. these toxic alkaloids are distributed mainly in senecio (compositae), crotalaria (legominosae) and heliotropium (boraginaceae) species. plants containing these alkaloids cause significant mammalian morbidity and mortality, especially in humans. upon ingestion, metabolic activatio...

garciniavalline (1), a novel aporphinoid alkaloid, in addition to four known alkaloids,cleistopholine (2), o-methylmoschatoline (3), (-)-oliveroline (4) and (-)-oliveridine (5), wereisolated and characterized from garcinia parvifolia miq. stem bark. structural elucidation ofthese compounds was established by spectroscopic methods. among them, alkaloids (2) and (4)exhibited antiplasmodial activi...

The ergot alkaloid ergovaline has demonstrated a persistent and sustained contractile response in several different vascular models. It was hypothesized that different alkaloids isolated from tall fescue (Lolium arundinaceum) will contribute to this contractile response differently. The objective was to compare contractile-response patterns of single additions of the ergoline alkaloids lysergic...

[email protected] Abstract Alkaloids are nitrogen-containing compounds found in plants. Most are highly valued for their role in wide array of ailments such as anti-malarial, anti-cancerous, analgesics, and many more. In lights of tremendous interest in recent years on the chemistry and pharmacological properties of alkaloids, comprehensive data have been collected. Forest industrie...

Polyhydroxylated pyrrolidine, piperidine, and indolizidine alkaloids are of great interest because of their specific glycosidase inhibitory activity." Moreover, it has recently been found in our laboratories that swainsonine (1), a representative of the polyhydroxylated indolizidine alkaloids, has an immunostimulating activity, possibly as a result of its glycosidase inhibitory activity.21 This...

A total of 20 new indole alkaloids comprising mainly oxidized derivatives of macroline- (including alstofonidine, a macroline indole incorporating a butyrolactone ring-F), pleiocarpamine-, and sarpagine-type alkaloids were isolated from the bark and leaf extracts of Alstonia angustifolia. The structures and relative configurations of these alkaloids were determined using NMR and MS analyses and...

The present report deals with the pharmacological properties of a series of quaternary tetrahydrobenzylisoquinoline, phenylethylamine and phenanthropyridine alkaloids, isolated from Magnolia and Cocculus plants by Prof. Tomita et al. (1). Marsh et al. (2) reported that some of the quaternary alkaloids isolated from the Cocculus plants showed a considerable curare-like activity. Ogiu and Morita ...