BACKGROUND Identifying agents that inhibit amyloid beta peptide (Aβ) aggregation is the ultimate goal for slowing Alzheimer's disease (AD) progression. This study investigated whether the glycoside asiaticoside inhibits Aβ1-42 fibrillation in vitro. METHODS Fluorescence correlation spectroscopy (FCS), evaluating the Brownian diffusion times of moving particles in a small confocal volume at th...

BACKGROUND The persistent appearance of viral strains that causes a resistant viral infection has led to continuous trials for the design and development of novel antiviral compounds. Benzoquinazoline compounds have been reported to exhibit an interesting antiviral activity. This work aims to study and evaluate the antiviral activity of a newly prepared 2-thioxo-benzo[g]quinazolin-4(3H)-one ser...

Background Justicia gendarussa Burm f. (Achanthaceae) has been known as traditional medicine in Indonesia. It contains of flavonoids and alkaloids. This study was conducted to evaluate the effect of J. gendarussa on the profile of IFN-γ on mice (Mus musculus). Molecular docking test was also conducted to determine the interaction of alkaloids and flavonoids on the J. gendarussa leaves against I...

Tuberculosis is known to be a fatal infectious disease causing a large number of deaths every year. The causative agent of TB is the pathogenic bacteria Mycobacterium tuberculosis. Although vaccines and drugs have been developed, cases of TB infections are still widespread largely due to development of drug resistant strains of Mycobacterium tuberculosis which makes it imperative to search for ...

Abstract Objectives Presently, the pandemic of COVID-19 has worsened situation worldwide and received global attention. The United States America have highest numbers a patient infected by this disease followed Brazil, Russia, India many other countries. Moreover, lots research is going on to find out effective vaccines or medicine, but still, no potent vaccine drug discovered cure COVID-19. As...

Backgrounds Justicia gendarussa Burm.f. has been known to have anti-HIV activity. This study was conducted to evaluate the effect of incubation time on the antiviral activity of the J. gendarussa leaves extract on HIV-infected MT-4 cells in vitro. Molecular docking test was also conducted to determine the interaction of alkaloids and flavonoids on the J. gendarussa leaves against HIV-1 reverse ...

Background Software container technology such as Docker can be used to package and distribute bioinformatics workflows consisting of multiple software implementations and dependencies. However, Docker is a command line-based tool, and many bioinformatics pipelines consist of components that require a graphical user interface. Results We present a container tool called GUIdock-VNC that uses a ...

eScience demands large-scale computing clusters to support the efficient execution of resource-intensive scientific applications. Virtual Machines (VMs) have introduced the ability to provide customizable execution environments, at the expense of performance loss for applications. However, in recent years, containers have emerged as a light-weight virtualization technology compared to VMs. Inde...

Docker containers wrap up a piece of software together with everything it needs for the execution and enable to easily run it on any machine. For their execution in the Cloud, we need to identify an elastic set of virtual machines that can accommodate those containers, while considering the diversity of their requirements. In this paper, we briefly describe our formulation of the Elastic provis...