Introduction. The aim of the molecular and cellular pathology group in the Bremerhaven Workshop was to test for evidence of biological changes which were indicative of exposure to toxic chemicals, as well as to their adverse effects. Much of the study focused on the liver of the flatfish dab Llmanda limanda. The liver was chosen as it is an integrator of many functions including detoxication/ac...

Alzheimer's disease is the fourth major cause of death in the developed world and is a major social and health care issue. Recent molecular genetic research has shed new light on the pathogenesis of this debilitating condition.

The identification of several types of familial colorectal cancer has led to the discovery of some of the genes involved in these diseases. It was subsequently shown that somatic mutations of these genes (APC, mismatch repair genes, TP53) also occur in sporadic colorectal cancer. Gradually, this molecular information is being incorporated into the standard histopathological analysis of colorect...

Malignant gliomas, the most common type of primary brain tumor, are a spectrum of tumors of varying differentiation and malignancy grades. These tumors may arise from neural stem cells and appear to contain tumor stem cells. Early genetic events differ between astrocytic and oligodendroglial tumors, but all tumors have an initially invasive phenotype, which complicates therapy. Progression-asso...

This chapter includes discussion of the molecular pathology of tissue, blood, urine, and expressed prostatic secretions. Because we are unable to reliably image the disease in vivo, a 12 core method that oversamples the peripheral zone is widely used. This generates large numbers of cores that need to be carefully processed and sampled. In spite of the large number of tissue cores, the amount o...