Modifying threat related biases in attention and interpretation has been shown to successfully reduce global symptoms of anxiety in high anxious and clinically anxious samples (termed Cognitive Bias Modification, CBM). However, the possibility that CBM can be used as a way to prevent anxiety associated with an upcoming real-life stressful event in vulnerable populations has yet to be systematic...

Transposable elements (TEs) are mobile genetic elements, highly enriched in heterochromatin, that constitute a large percentage of the DNA content of eukaryotic genomes. Aging in Drosophila melanogaster is characterized by loss of repressive heterochromatin structure and loss of silencing of reporter genes in constitutive heterochromatin regions. Using next-generation sequencing, we found that ...

OBJECTIVE To determine the importance of rhythm regulation or rate control in patients with permanent atrial fibrillation (AF) and normal left ventricular function. PATIENTS AND INTERVENTIONS Thirty six patients with a mixed fast and slow ventricular response rate to their AF were randomised to either His bundle ablation (HBA) and VVIR pacemaker (HBA group) or VVI pacemaker and atrioventricul...

INTRODUCTION Exciting advances in the understanding of rheumatoid arthritis (RA) and its pathogenesis are providing new hope for those suffering from this debilitating disease. A currently incurable autoimmune disorder, RA is one of the most common forms of inflammatory arthritis, causing suffering, disability (90% within 20 years will become clinically disabled), and even premature death. Many...

This study investigated the effectiveness of using antecedent persuasive stimulation and response-contingent praise, within a small discussion group context, to modify the rate of verbal participation of Ss in an independent, classroom situation. Ss were 96 male college students who were divided into 12 treatment subgroups and 4 control subgroups of 6 Ss each. 3 treatment conditions were employ...

Our objective was to compare self-reported health-related quality of life (HRQOL) for U.S. veterans with multiple sclerosis (MS) on disease-modifying agents with provider reports of HRQOL from standard disability measures. We conducted a 3-year prospective observational study of 204 subjects who used interferon beta or glatiramer acetate and compared subjects' responses on the Veterans Short-Fo...

background osteoporosis and related fractures due to discomfort, disability, decreased quality of life and death is a major health problem in the world. according to the importance of recording and reporting osteoporosis, lifestyle in growth duration, during teenage, is the most risk factor that determines osteoporosis in adolescents and the elderly. the aim of this study was assessing adolesce...