OBJECTIVE To increase power to detect modifier loci conferring susceptibility to specific phenotypes such as disease diagnoses which are part of a broader disorder spectrum by jointly modeling a modifier and a broad susceptibility gene and to identify modifier loci conferring specific susceptibility to schizophrenia (SZ) or to bipolar disorder (BP) using the approach. METHODS We implemented a...

In this research, polyvinylchloride based composite heterogeneous cation exchange membranes were prepared by the solution casting technique. Chitosan-co-iron nickel oxide nanoparticles were utilized as membrane surface modifier to improve the membranes electrochemical properties. The effect of additive nanoparticle concentration in the modifier solution on the properties of composite membranes ...

The evolution of genetic systems has been analyzed through the use of modifier gene models, in which a neutral gene is posited to control the transmission of other genes under selection. Analysis of modifier gene models has found the manifestations of an "evolutionary reduction principle": in a population near equilibrium, a new modifier allele that scales equally all transition probabilities b...

Every year thousands of people in the USA are diagnosed with small intestine and colorectal cancers (CRC). Although environmental factors affect disease etiology, uncovering underlying genetic factors is imperative for risk assessment and developing preventative therapies. Familial adenomatous polyposis is a heritable genetic disorder in which individuals carry germ-line mutations in the adenom...

We present a model for inducing sentential argument structure, which distinguishes arguments from optional modifiers. We use this model to study whether representing an argument/modifier distinction helps in learning argument structure, and whether a linguistically-natural argument/modifier distinction can be induced from distributional data alone. Our results provide evidence for both hypotheses.

Modifier logics are considered as generalizations of "classiea1" modal logics. Thus modifier logics are soeanled multimodal logios. Multimodality means here that the basic logics are modal logics with graded modalities. The interpretation of modal operators is more generan, too. Leibniz's mottvating semantical ideas (see [8]. p. 20-21) givejustification to these generalizations. Semantics of ca...

We explore the evolution of dominance at polymorphisms maintained either by overdominant selection or by migration-selection balance. At such balanced polymorphisms, heterozygotes remain at appreciable frequencies over long periods of time, allowing extensive modification of dominance to occur. The strength of selection favoring a modifier of dominance is roughly proportional to the probability...