The use of stem cells to support tissue repair is facilitated by loading of the therapeutic cells with magnetic nanoparticles (MNPs) enabling magnetic tracking and targeting. Current methods for magnetizing cells use artificial MNPs and have disadvantages of variable uptake, cellular cytotoxicity and loss of nanoparticles on cell division. Here we demonstrate a transgenic approach to magnetize ...

In this work, we report synthesis of surface modified superparamagnetic iron oxide nanoparticles (SPION) by co-precipitation method using FeSO4.7H2O and Fe2(SO4)3.5H2O as precursors and trisodium citrate dihydrate as surfactant. Surface modification of the as prepared samples was performed in pot by sol-gel precipitation method u...

Superparamagnetic iron oxide-based nanoparticles (SPIONs) are promising carriers as targeted drug delivery vehicles, because they can be guided to their target with the help of an external magnetic field. Functionalization of nanoparticles' surface with molecules, which bind with high affinity to receptors on target tissue significantly facilitates delivery of coated nanoparticles to their targ...

in this paper, a nanostructured modified electrode was fabricated by incorporating of 2,2′-[1,9-nonanediylbis(nitriloethylidyne)]-bis-hydroquinone (nnh) as a newly synthesized modifier and tio2 nanoparticles to the carbon paste (mtcpe) and then was used for the electroanalysis of epinephrine (ep). the electrochemical studies were carried out by using cyclic voltammetry, chronoamperometry and di...

Amplification-free detection of nucleic acids in complex biological samples is an important technology for clinical diagnostics, especially in the case where the detection is quantitative and highly sensitive. Here we present the detection of a synthetic DNA sequence from Herpes Simplex Virus-1 within swine cerebrospinal fluid (CSF), using a sandwich-like, magnetic nanoparticle pull-down assay....

Bi-phase dispersible core-shell FeAu@ZnO magneto-opto-fluorescent nanoparticles were synthesized by a modified nanoemulsion process using poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (PEO-PPO-PEO) as the surfactant. The morphology and crystal structure of the nanoparticles were studied by TEM/HRTEM and XRD. The nanoparticles manifest soft ferromagnetic and/or n...

The development of nanotechnology is responsible for an increase in the achievements in medical diagnostics and in the preparation of new therapeutic vehicles. In particular, magnetic nanoparticles with a modified surface are a very attractive alternative to deliver therapeutic agents. We describe the modification of the surface of the iron oxide nanoparticles with aminophosphonic acids by appl...

We have used tungestophosphoric acid to catalyze oxidative amidation reaction from benzyl alcohols and methylarens with hydrochloride salts of amines. To achieve this purpose, modified magnetic nanoparticles (γ-Fe2O3@SiO2@H3PW12O40) were applied as catalyst and TBHP as external oxidant. After optimizing, different derivates of be...

In the present study, magnetic core-shell manganese ferrite nanoparticles (MCMNP) were synthesized and used for construction of a magnetic core-shell manganese ferrite nanoparticles modified screen-printed carbon electrode (MCSNP-SPCE). Cyclic voltammetry was used to study the electrochemical behavior of chlorpromazine (CPZ) and its determination was conducted by applying square wave voltammetr...