Arsenic exposure mainly through food and water has been shown to be associated with increased incidence of numerous cancers and non-cancer harmful health. It is also used in cancer chemotherapy and treatment of several cancer types due to its apoptogenic effects in the various cancer and normal cell lines. We have already reported that liver is the storage site and important target organ in As ...

Mitophagy is one of the selective autophagy pathways that catabolizes dysfunctional or superfluous mitochondria. Under mitophagy-inducing conditions, mitochondria are labeled with specific molecular landmarks recruit machinery to surface mitochondria, enclosed into autophagosomes, and delivered lysosomes (vacuoles in yeast) for degradation. As damaged major sources reactive oxygen species, mito...

acrolein (acr) is α, β unsaturated aldehyde that exists extensively in the environment and (thermally processed) foods. it can also be generated through endogenous metabolism. the aim of this study was to investigate the possible protective role of pentoxifylline (ptx) is a non-selective phosphodiesterase (pde) inhibitor on toxicity of acr. in this study, oxidative damage were measured by marke...

conclusions in conclusion, at measurement can be beneficial for the safety or recovery of malathion-induced toxic injury in liver tissue and liver mitochondria. results in liver tissue, the activity of lpo and cat was higher in the malathion group in comparison to controls. at reduced malathion-induced lpo, sod, cat, and gpx in rat liver. coadministration of at with malathion improved lpo, sod,...

The state of lipid peroxidation (LPO), respiration and oxidative phosphorylation, mitochondrial permeability transition pore (mPTP) antiradical activity rat liver mitochondria in streptozotocin (STZ)-induced diabetes condition were studied, considered the ways correction detected membrane damages with use gossitan, isolated from cotton plant Gossypium hirsutum L. It was shown that rate states V...

Neuroglobin is the third member of globin family to be identified in 2000 neurons both human and mouse nervous systems. an oxygen-binding found within central system as well peripheral neurons, that produces a protective effect against hypoxic/ischemic damage induced by promoting oxygen availability mitochondria. Numerous investigations have demonstrated impaired neuroglobin functioning implica...

Mitochondria are cellular organelles which generate adenosine triphosphate (ATP) molecules for the maintenance of energy through oxidative phosphorylation. They also regulate a variety processes including apoptosis and metabolism. Of interest, inner part mitochondria—the mitochondrial matrix—contains circular molecule DNA (mtDNA) characterised by its own transcriptional machinery. As with genom...