Exercise training (ET) is an important non-drug adjuvant therapy against many human diseases, including cardiovascular diseases. The appropriate ET intensity induces beneficial adaptions and improves physiological function cardiopulmonary fitness. mechanisms of exercise-induced cardioprotective effects are still not fully understood. However, mounting evidence suggest that microRNAs (miRNAs) pl...

Background: Micro RNAs (miRNAs) are a pivotal part of non-protein-coding endogenous small RNA molecules that regulate the genes involved in plant growth and development, and respond to biotic and abiotic environmental stresses posttranscriptionally.Objective: In the present study, we report the results of a systemic search for identifi cation of new miRNAs in B. rapa using homology-based ...

Objective The study aimed to explore the miRNA and mRNA biomarkers in post-stroke depression (PSD) develop a miRNA–mRNA regulatory network reveal its potential pathogenesis. Methods transcriptomic expression profile was obtained from GEO database using accession numbers GSE117064 (miRNAs, stroke vs. control) GSE76826 [mRNAs, late-onset major depressive disorder (MDD) control]. Differentially ex...

Objective(s): microRNAs are small non-coding molecules that regulate gene expression in various biological processes. T-cell acute lymphoblastic leukemia (T-ALL) is a malignancy accompanied with genetic aberrations and accounts for 20% of children’s and adult’s ALL. Notch signaling pathway dysregulation occurs in 60% of T-ALL cases. In the present study, we aimed to de...

A Central nervous system (CNS) hemorrhage is bleeding in or around the brain and spinal cord. Reasons of CNS hemorrhage include high blood pressure, cancers, drug abuse, abnormally weak blood vessels that leakage, and trauma. Regression of CNS bleeding was confirmed to be relatively repetitive in patients with severe FV, FX, FVII and FXIII deficiencies. Generally in CNS hemorrhage, radiological...

Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma. MicroRNAs (miRNAs) are endogenous small RNA, which can regulate gene expression at the post-transcriptional level. MiRNA profiling has shown a great potential as novel diagnostic and prognostic biomarkers. The present study was performed at the Nemazee Teaching Hospital (Shiraz, Iran) from 2011 to 2013.The aim of thi...

Abstract Background Micro-RNAs (miRNAs) have been reported as an emerging biomarker in many cancer types. They are used diagnostic and prognostic biomarkers could be considered therapeutic targets treating the same. Main body Studies proven that miRNAs play essential role molecular pathophysiology, including oral squamous cell carcinoma. Distinct expression profiles of different demonstrated Am...