نتایج جستجو برای: mir 23b
تعداد نتایج: 45439 فیلتر نتایج به سال:
Patients at the same pathological stage of esophageal cancer (EC) that received the same surgical therapy by the same surgeon may have distinct prognoses. The current study aimed to explore the possibility of differentially- expressed microRNAs (miRNAs) underlying this phenomenon. Samples were collected from EC patients at the same tumor node metastasis (TNM) stage but with different prognoses....
Herein, we aimed at identifying global transcriptome microRNA (miRNA) changes and miRNA target genes in lung adenocarcinoma. Samples were selected as training (N = 24) and independent validation (N = 34) sets. Tissues were microdissected to obtain >90% tumor or normal lung cells, subjected to miRNA transcriptome sequencing and TaqMan quantitative PCR validation. We further integrated our data w...
*To whom correspondence should be addressed: Rajvir Dahiya, Ph.D. Professor and Director, Urology Research Center (112F), V A Medical Center and UCSF, 4150 Clement Street, San Francisco, CA 94121. Phone: 415-750-6964; Fax: 415-750-6639 E-mail: [email protected]. Running title: miR-23b in prostate cancer. Conflict of Interest: The authors disclose no potential conflicts of interest. Word ...
Abstract Multiple myeloma (MM) is a plasma cell malignancy with diverse clinical phenotypes and molecular heterogeneity not completely understood. Differentially expressed genes (DEGs) miRNAs (DEMs) in MM may influence disease pathogenesis, presentation / drug sensitivities. But these signatures overlap meagrely plausibly due to complexity of genome, diversity primary cells studied, technologie...
Dendritic cells (DCs) belong to the immune system and are particularly studied for their potential to direct either an activated or tolerogenic immune response. The roles of microRNAs (miRNAs) in posttranscriptional gene expression regulation are being increasingly investigated. This study's aim is to evaluate the miRNAs' expression changes in prepared human immature (iDCs), activated (aDCs), a...
Atherosclerosis preferentially occurs in arterial regions exposed to disturbed flow, in part, due to alterations in gene expression. MicroRNAs (miRNAs) are small, noncoding genes that post-transcriptionally regulate gene expression by targeting messenger RNA transcripts. Emerging evidence indicates that alteration of flow conditions regulate expression of miRNAs in endothelial cells both in vit...
Abstract Study question To investigate whether microRNA-23a/b-3p targets spermatogenesis-related transcripts and this targeting impacts their expression contents in patients with subfertility. Summary answer The higher of lower 11 tested target genes are associated men subfertility What is known already Spermatogenesis a complex highly regulated process, many involved, the levels which strongly...
MicroRNAs (miRNAs) play a crucial role in tissue development and the pathology of many diseases, however, the effects and roles of miRNAs in the development of semen abnormalities in infertile males have not yet been investigated. In this study, we analyzed and compared the miRNA expression profiles of abnormal semen from 86 infertile males with normal semen from 86 healthy males using an miRNA...
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