نتایج جستجو برای: mir 143
تعداد نتایج: 57115 فیلتر نتایج به سال:
We are just beginning to understand how microRNAs (miRNAs) are involved in tumor-related processes in humans. Applying real-time RT-PCR, we investigated the miR-31, miR-143 and miR-145 expression in 98 primary CRC specimens, along with the corresponding normal mucosa specimens, and analyze the relationship of their expression with clinicopathological features. Our results showed the miR-31 expr...
MicroRNAs (miRNAs, miRs) have emerged as important post-transcriptional regulators of gene expression. In vascular pathologies, the miR-143/145 cluster has attracted particular attention. The miR-143/145 cluster is encoded by a bicistronic transcript, and regulates the differentiation, plasticity and contractile function of vascular smooth muscle cells (VSMCs). VSMCs from miR143/145–deficient m...
Hirschsprung disease (HSCR) is a genetic disorder of neural crest development. It is also believed that epigenetic changes plays a role in the progression of this disease. Here we show that the MIR143 host gene (MIR143HG), the precursor of miR-143 and miR-145, decreased cell proliferation and migration and forms a negative feedback loop with RBM24 in HSCR. As RBM24 mRNA is a target of miR-143, ...
Liposarcoma remains the most common mesenchymal cancer, with a mortality rate of 60% among patients with this disease. To address the present lack of therapeutic options, we embarked upon a study of microRNA (miRNA) expression alterations associated with liposarcomagenesis with the goal of exploiting differentially expressed miRNAs and the gene products they regulate as potential therapeutic ta...
Downregulation of the miR-143/145 microRNA (miRNA) cluster has been repeatedly reported in colon cancer and other epithelial tumors. In addition, overexpression of these miRNAs inhibits tumorigenesis, leading to broad consensus that they function as cell-autonomous epithelial tumor suppressors. We generated mice with deletion of miR-143/145 to investigate the functions of these miRNAs in intest...
Therapeutic applications of microRNAs (miRNAs) in RAS-driven glioma were valuable, but their specific roles and functions have yet to be fully elucidated. Here, we firstly report that miR-143 directly targets the neuroblastoma RAS viral oncogene homolog (N-RAS) and functions as a tumor-suppressor in glioma. Overexpression of miR-143 decreased the expression of N-RAS, inhibited PI3K/AKT, MAPK/ER...
Our previous studies have suggested a protective role for H. pylori infection in the prognosis of gastric cancer. Based on those findings, we hypothesized that H. pylori-positive and -negative gastric cancers may exhibit different growth patterns and pathobiological behaviors, indicating different mechanisms of cancer progression. By microarray analysis, we studied miRNAs expression profiles in...
زمینه و هدف: میکروRNAها، RNAهای غیرکدکننده به طول تقریبا 22 نوکلئوتید بوده که با اتصال بهmRNA ژن هدف، بیان آن را تنظیم و نقش برجسته خود را به عنوان انکومیر یا میکروRNA سرکوبگر تومور، اعمال مینمایند. تغییرات بیان میکروRNAها نقش اساسی در پاتوبیولوژی سرطان‌های متعدد دارد. در این مطالعه میزان بیانmiR-143 و miR-338 در تومور معده و حاشیه آن مورد مقایسه قرار گرفته است. روش کار: این مطالعه یک مطالعه...
Pekow J, Meckel K, Dougherty U, Butun F, Mustafi R, Lim J, Crofton C, Chen X, Joseph L, Bissonnette M. Tumor suppressors miR143 and miR-145 and predicted target proteins API5, ERK5, K-RAS, and IRS-1 are differentially expressed in proximal and distal colon. Am J Physiol Gastrointest Liver Physiol 308: G179–G187, 2015. First published December 4, 2014; doi:10.1152/ajpgi.00208.2014.—The colon dif...
BACKGROUND & AIMS TGF-β1 is an abundant cytokine present in the tumour microenvironment. It has been shown to trigger versican expression in human osteosarcoma cells, which may account for the metastatic potential of these cells. However, the underlying mechanism of TGF-β1-mediated metastasis remains unclear. The aim of this study was to evaluate the roles of versican in TGF-β1-induced osteosar...
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