نتایج جستجو برای: mir 122

تعداد نتایج: 60190  

2014
Sheng-Chun Wang Xiao-Lin Lin Jing Li Ting-Ting Zhang Hui-Yan Wang Jun-Wen Shi Sheng Yang Wen-Tao Zhao Rao-Ying Xie Fang Wei Yu-Juan Qin Lin Chen Jie Yang Kai-Tai Yao Dong Xiao

The loss of microRNA-122 (miR-122) expression is strongly associated with increased invasion and metastasis, and poor prognosis of hepatocellular carcinoma (HCC), however, the underlying mechanisms remain poorly understood. In the present study, we observed that miR-122 over-expression in HCC cell lines Sk-hep-1 and Bel-7402 triggered the mesenchymal-epithelial transition (MET), as demonstrated...

2012
Oliver Waidmann Verena Köberle Friederike Brunner Stefan Zeuzem Albrecht Piiper Bernd Kronenberger

BACKGROUND Liver cirrhosis is associated with high morbidity and mortality. MicroRNAs (miRs) circulating in the blood are an emerging new class of biomarkers. In particular, the serum level of the liver-specific miR-122 might be a clinically useful new parameter in patients with acute or chronic liver disease. AIM Here we investigated if the serum level of miR-122 might be a prognostic parame...

Journal: :Genes & development 2009
David Gatfield Gwendal Le Martelot Charles E Vejnar Daniel Gerlach Olivier Schaad Fabienne Fleury-Olela Anna-Liisa Ruskeepää Matej Oresic Christine C Esau Evgeny M Zdobnov Ueli Schibler

In liver, most metabolic pathways are under circadian control, and hundreds of protein-encoding genes are thus transcribed in a cyclic fashion. Here we show that rhythmic transcription extends to the locus specifying miR-122, a highly abundant, hepatocyte-specific microRNA. Genetic loss-of-function and gain-of-function experiments have identified the orphan nuclear receptor REV-ERBalpha as the ...

2015
Chunxian Zeng Yun-Long Wang Chen Xie Ye Sang Tuan-Jie Li Min Zhang Ruizhi Wang Qi Zhang Limin Zheng Shi-Mei Zhuang

Transforming growth factor-β (TGF-β) is a potent cytokine that promotes the development of fibrogenic cells, stimulates the expression of fibrosis-related genes, and consequently results in hepatic fibrogenesis. The involvement of miRNAs in this process remains largely unknown. We showed that miR-122 was substantially expressed in hepatic stellate cells (HSCs) and fibroblasts, the major sources...

2017
Peter Willeit Philipp Skroblin Alexander R Moschen Xiaoke Yin Dorothee Kaudewitz Anna Zampetaki Temo Barwari Meredith Whitehead Cristina M Ramírez Leigh Goedeke Noemi Rotllan Enzo Bonora Alun D Hughes Peter Santer Carlos Fernández-Hernando Herbert Tilg Johann Willeit Stefan Kiechl Manuel Mayr

MicroRNA-122 (miR-122) is abundant in the liver and involved in lipid homeostasis, but its relevance to the long-term risk of developing metabolic disorders is unknown. We therefore measured circulating miR-122 in the prospective population-based Bruneck Study (n = 810; survey year 1995). Circulating miR-122 was associated with prevalent insulin resistance, obesity, metabolic syndrome, type 2 d...

Journal: :Molecular medicine reports 2012
Xianfeng Ding Jianv Ding Jing Ning Fan Yi Jiankui Chen Deyao Zhao Jiaping Zheng Zicai Liang Zhiyuan Hu Quan Du

Liver-specific microRNA-122 (miR-122) is involved in the replication of hepatitis C virus (HCV) and its potential as a target for antiviral intervention was recently assessed. However, the use of circulating miR-122 in the evaluation of liver function has never been reported. In the present study, changes of serum miRNA levels were first evaluated in acute human hepatotoxicity due to paraquat e...

2018
Xia Wu Yingzhuo Yang Yike Huang Yang Chen Tianying Wang Shuo Wu Lei Tong Yan Wang Lexun Lin Meili Hao Zhao-Hua Zhong Fengmin Zhang Wenran Zhao

Hepatocellular carcinoma (HCC) is one of the common cancers worldwide, especially in developing countries. Although the chronic infections of hepatitis B and C viruses have been established as the etiological factors of HCC, the mechanism for the tumorigenesis and development of HCC is still unclear. The liver-specific microRNA-122 (miR-122), an established tumor-suppressor miRNA, is often down...

2011
Jie Su Huricha Baigude Joshua McCarroll Tariq M. Rana

MicroRNAs (miRNAs) are small endogenous non-coding RNAs that regulate post-transcriptional gene expression and are important in many biological processes. Disease-associated miRNAs have been shown to become potential targets for therapeutic intervention. Functions of miRNAs can be inhibited by using antisense oligonucleotides, called anti-miRs, complimentary to the miRNA sequences. Here, we sho...

2009
Omar F. Laterza Lee Lim Philip W. Garrett-Engele Katerina Vlasakova Nagaraja Muniappa Wesley K. Tanaka Jason M. Johnson Joseph F. Sina Thomas L. Fare Frank D. Sistare Warren E. Glaab

RESULTS: We observed increases in plasma concentrations of miR-122, miR-133a, and miR-124 corresponding to injuries in liver, muscle, and brain, respectively. miR-122 and miR-133a illustrated specificity for liver and muscle toxicity, respectively, because they were not detectable in the plasma of animals with toxicity to the other organ. This result contrasted with the results for alanine amin...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تربیت مدرس - دانشکده علوم پزشکی 1393

توانایی تمایز سلول های بنیادی جنینی به سمت سلول های شبه کبدی باعث ایجاد فرصت های بسیاری در زمینه مهندسی بافت کبد و کاربردهای درمانی خواهد شد. در این مطالعه، ما توانایی القاء تمایز کبدی در سلول های بنیادی جنینی موشی را به واسطه ترانسدیوس با سه فاکتور hnf4?، foxa2 و mir-122 به صورت منفرد و ترکیبی مورد مطالعه قرار دادیم. علاوه بر این سلول های بنیادی جنینی موشی با بهترین ترکیب ژنی که القاء کبدی را ...

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